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- A group of doctors at Chastain Memorial Hospital face personal and professional challenges on a daily basis.
- The doctors of Chastain are surrounded by new rules and doctors, as Red Rock Mountain Medical takes over the hospital; Conrad finds himself in a dangerous situation when the construction for a neurosurgery center causes a gas explosion.
- In an effort to save Chastain, Bell considers selling the hospital to a conglomerate, but Kit tries to make him see that the negatives will outweigh the positives. With Conrad's help, Nic tracks down Kyle and pleads for him to reconsider donating a kidney to Jessie. Meanwhile, Mina voices her concern to Austin when Shira is assigned to Micah's surgery and Devon fights for the care of a patient whom the doctors suspect is uninsured.
- When a police officer brings in an injured criminal, the staff must keep him alive; Nic gets roped into a surgical rotation with Cain that leaves her questioning the way he operates; Conrad makes a shocking discovery about the hospital.
- Intending to garner publicity for the hospital, Cain tries to recruit Bell and Kit on a dangerous surgery; the Raptor develops an emotional attachment to a patient; Mina's friend arrives with shocking news.
- After a plane crashes in Atlanta, Devon is overcome by guilt at the thought that he could have prevented the tragedy. Bell, who was a passenger on the plane, makes it his personal mission to save the life of the man seated next to him. Meanwhile, Adaku returns to ask Mina a big favor, the Raptor struggles with telling his adoptive parents about meeting his biological father and Conrad and Nic consider risking it all to investigate a drug that might be linked to Jessie's death.
- Conrad doubts Devon's judgement when a patient who was pronounced dead suddenly revives; Cain and Nic butt heads over the care of a white supremacist; The Raptor and Mina uncover new information about Red Rock Medical.
- On National Nurses' Day, Chastain's nurses are severely understaffed and overworked, leaving them all feeling exhausted and underappreciated. Cain performs a dangerous surgery on a new patient he won in a game of poker. Meanwhile, Conrad discovers that his father has been administered the same drug that he fears played a role in Jessie's death, The Raptor comes face-to-face with his birth mother for the first time and Irving attempts to take the next step in his relationship with Jessica.
- Conrad comes under fire when a former patient files a malpractice lawsuit against him, putting Bell in a difficult position with Red Rock. When Devon discovers that his VIP patient has a life-threatening brain condition, the doctors ban together to perform a risky surgery. Meanwhile, Mina discovers that Adaku has a dangerous heart condition that puts her and the baby at risk, and Kyle forms a personal relationship with a patient.
- When one of Chastain's own is brought into the emergency room with life-threatening injuries, the staff rallies around each other to try to save her life, while disagreements over how to best handle her care put Cain at odds with the rest of the doctors. Also, Bell is met with an unexpected response when he voices concerns regarding the nursing shortage that Nic brought to his attention. Meanwhile, Conrad turns heads when he shares data about Hemopleatin, and Kyle begins volunteering at the hospital.
- Upon dubbing Thanksgiving "the most dangerous day of the year," Devon and Irving are inundated with patients in the ER. When an A-list celebrity enters the hospital after swallowing a wish bone, Logan Kim assigns a new surgeon to the case in the hopes of garnering extra publicity. Meanwhile, tensions run high at the Raptor home when he hosts his biological and adoptive families for a Thanksgiving dinner and Kyle interrupts Nic and Conrad's low-key plans.
- On Devon's last day as an intern, he and Conrad are faced with a moral dilemma over a suicidal patient who is in need of a liver transplant. When Bell discovers that Cain is keeping braindead patients alive in order to boost his survival rates and add to Red Rock's profits, he decides to take matters into his own hands. Meanwhile, Adaku goes into early labor, causing a strain on her heart and Mina is left in doubt over how to best handle her care.
- After being terminated from Chastain, Conrad has difficulty figuring out his next step and distracts himself by accompanying a patient on a zero-gravity adventure. In his first move as the new Chief of Surgery, Cain puts the doctors on a commission-based pay system, which causes Devon's new intern to agree to a procedure before weighing the risks. Meanwhile, Mina struggles with taking care of Adaku's baby and Bell's supplement company gets its big break.
- While working at their non-profit clinic three hours outside of Atlanta, Nic and Mina treat a patient with a failing heart VAD, forcing them to find a new battery in time to save her life. Conrad gets a call from a previous patient in crisis after being sued by Red Rock for medical expenses he can't afford. Meanwhile, Devon's VIP patient, Nadine, returns to the ER and Cain tries to get close to Bell's business partner from the supplement company.
- Upon meeting with a high-profile soccer player suffering from mysterious symptoms, Conrad ends up back at Chastain and faces an angry Logan Kim. When Bell and the Raptor come up empty-handed in regard to a diagnosis, the doctors take note on how talented Conrad truly is. Nic springs into action when she notices Kyle falling into a deep depression and fears he could be suicidal.
- Cain feels disrespected by Logan Kim when he is left out of a major decision regarding Conrad. Meanwhile, the doctors work together to try to save the lives of two big Red Rock donors who were involved in a jet skiing accident. Then, Irving and Devon realize that three of their patients, all with different symptoms, could actually be triggered by the same thing. Also, Bell's supplement company proves to be more lucrative than anyone anticipated, but an unexpected snag could put it in jeopardy.
- The new neurosurgery center opens, and Nic is forced to work alongside Cain again; a heart transplant has an unexpected result; Bell asks Conrad to reexamine three patients who may have been poisoned.
- When Nadine's father comes to town for her birthday, Devon enlists the help of the whole staff, as well as one of his patients, to ensure that he makes the best first impression. Red Rock decides to cut the entire OBGYN department and Logan Kim leaves Conrad with the difficult task of letting the residents go. Meanwhile, Nic cares for a teenage patient whose condition is deteriorating.
- A renowned pediatric surgeon is called over to Chastain for an extremely difficult surgery on a newborn, but when she arrives, The Raptor and Devon realize she is not fit for surgery, resulting in a situation more complicated than they could have imagined. Meanwhile, a Dolly Parton drag queen is admitted to the ER after collapsing on stage, leading Bell and Ezra to a potentially life-saving discovery. Also, Nic and Conrad suspect their patient may be the victim of sex trafficking and Nadine delivers some surprising news to Devon.
- Conrad finds himself caught between his duties as a doctor and his loyalty to Kitt, when he discovers that her son-in-law may be suffering from a serious disease. While moonlighting at a long-term care facility, Devon and Nic make a shocking discovery about a former patient who fell victim to Cain's manipulative practices. Meanwhile, after jumping into a new opportunity as a TV doctor, Bell is left without any surgeries and The Raptor brings him in to help on an important case.
- When Cain becomes aware of an emergency situation breaking out at the hospital, he recruits Ezra to help keep it under wraps. Also, Nic works to come up with a support system for a patient in need of a lung transplant. Meanwhile, Kitt's son-in-law's condition continues to worsen.
- Just when Derek's condition seems to be improving, a severe complication arises, causing Kitt to fear that he may be the latest victim of Cain's cover-up. When Cain's former girlfriend is admitted to the hospital for surgery, the doctors finally get a glimpse into his personal life. Meanwhile, Conrad fills in Marshall on the emergency situation facing the hospital and Mina and The Raptor work on saving the heart of a salsa dancer.
- During the COVID-19 pandemic, the staff of Chastain does their best to treat the overwhelming number of patients that they face while also trying to protect their loved ones; Conrad and Nic get married.
- When Cain's elected surgery patient returns with complications, Mina and Raptor butt heads over how to handle the situation; Conrad and Devon treat a local Congresswoman.
- When Cain tries to be a hero at a crash scene, he is struck by a car, causing Chastain's doctors to put aside their personal issues to try and save his life.
- The staff works to diagnose a mother and daughter with a mysterious illness. Devon deals with a surprise visit from his mother. Mina makes a surprise proposal.
- Chastain is being dismantled, Doctors and surgeons are transferring and patients are panicking. Nic and Conrad announce they're going to be parents when another tragedy strikes.
- The hospital, now a public hospital, tries to adjust to the changes. When one of the surgeons who is scheduled to perform an important surgery decides to quit because of his pay reduction, they try to find another.
- When Conrad gets a call from his former army commander who is stranded and wounded in the forest, the trip to save him brings lots of old emotions to the surface.
- On Nic's first day back at Chastain, the man who attacked her is admitted to the ER, causing her to confront her trauma head-on. Cain, now in recovery, is self-conscious of his physical state and sets his eye on taking down Mina.
- Conrad and Bell treats the woman carrying Jake's future baby. Devon contemplates his love life. Mina receives a call that causes her to make a bold decision about her future.
- Just when Mina and The Raptor can see their future together, an unexpected complication throws a wrench in their plans.
- When a tornado touches down in Atlanta with Chastain directly in its path, the entire staff goes into crisis mode.
- With Nic's due date steadily approaching, she and Conrad plan a relaxing day off, but their plans are interrupted when a patient with a medical mystery sends them rushing back to Chastain.
- On the day of Nic's baby shower, Billie takes full control to make sure it goes smoothly, but a secret she's been hiding changes everything.
- The wait is over as Conrad and Nic welcome the arrival of their baby girl.
- A cyberattack sends the hospital into a tailspin and Kit has to decide whether to pay the ransom. Conrad has to balance work with being a new dad. Devon and Leela debate where their relationship is going.
- When Devon is found unconscious on the roof, the staff frantically retrace his steps to determine what happened. Billie fights with her son over a drug overdose. Bell helps Kit vet a new neurosurgeon.
- An accident brings a familiar patient into the ER, the doctors must face the reality of how to proceed with the best care while questioning every decision. The Raptor and Leela treat a patient dealing the long-term effects of COVID
- In trying to find a way to channel his emotions, Conrad puts all his effort in looking for answers. Raptor has a run-in with the police that ends up taking a surprising turn. Meanwhile, Leela begins noticing problems with a surgeon who has been Bell's mentor.
- While looking for a distraction on Halloween, Conrad treats a group of witches who send the ER into chaos. Also, Devon treats a patient who thinks he is being haunted by ghosts. Meanwhile, on the way back from his vacation, Bell picks up a hitchhiker who is not what he seems to be.
- Conrad brings a patient into the hospital who causes a high security crisis. An MMA brawl sends a well-known fighter to Chastain and all hands are on deck. Meanwhile, Bell and Raptor vie for the same position at the hospital, and Leela gets a visit from her sister.
- A new group of interns start their first day with Devon at Chastain. Kit and Bell try to convince Conrad to come back to Chastain. The Raptor's mother ends up back in the ER. Leela and Padma deal with an unexpected visit from their parents.
- Kit hires a surgical coach to watch over Bell and Raptor and help them brush up on their skills. Upon receiving attention from multiple women at the hospital, Conrad contemplates jumping back into the dating scene. Devon works with an elderly couple.
- 2018–202344mTV-147.7 (222)TV EpisodeConrad mentors Trevor whether to treat a patient whose luck seems to have run out.
- When the first day of Kit's experimental Flight Go team programme sends Conrad out into the field, he builds a new relationship with a fellow doctor along for the ride; Devon works with Trevor on a patient with a mysterious fever.
- A case turns personal for Conrad when the donor-recipient of Nic's heart is admitted to the emergency room; Bell is faced with a devastating diagnosis that causes him to make a heartbreaking decision.
- Conrad and Cade examine a child showing signs of abuse. Devon and Leela encounter a woman having trouble breathing. Meanwhile, Bell eyes an open seat on the State Medical Board and Billie decides it's time to confront her past.
- A tragic accident occurs at Jessica's sister's gender reveal party. Conrad, Irving and Trevor work on an influencer whose life is in danger due to a risky cosmetic procedure.
- When Billie's past mistakes are exposed, the team struggles to find a way to support her. The nursing shortage hits Chastain. A simple cleaning job goes horribly awry.