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- CreatorDavid KohanMax MutchnickStarsEric McCormackDebra MessingMegan MullallyGay lawyer Will and straight interior designer Grace share a New York City apartment. Their best friends are gleeful and proud gay Jack and charismatic, filthy-rich, amoral socialite Karen.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorTina FeyStarsTina FeyAlec BaldwinTracy MorganLiz Lemon, head writer of the sketch-comedy show "TGS with Tracy Jordan", must deal with an arrogant new boss and a crazy new star while trying to run a successful television show without losing her mind.
- CreatorSteven LevitanChristopher LloydStarsEd O'NeillSofía VergaraJulie BowenThree different, but related, families face trials and tribulations in their own uniquely comedic ways.
- CreatorKevin BiegelBill LawrenceStarsCourteney CoxChrista MillerBusy PhilippsFollows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoA woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- CreatorJenji KohanStarsMary-Louise ParkerHunter ParrishAlexander GouldWhen a suburban mother turns to dealing marijuana in order to maintain her privileged lifestyle after her husband dies, she finds out just how addicted her entire neighborhood already is.
- CreatorDoug EllinStarsKevin ConnollyAdrian GrenierKevin DillonFilm star, Vince Chase, navigates the vapid terrain of Los Angeles with a close circle of friends and his trusty agent.
- CreatorLarry DavidJerry SeinfeldStarsJerry SeinfeldJulia Louis-DreyfusMichael RichardsThe continuing misadventures of neurotic New York City stand-up comedian Jerry Seinfeld and his equally neurotic New York City friends.
- CreatorMark BrazillBonnie TurnerTerry TurnerStarsTopher GraceLaura PreponMila KunisA comedy revolving around a group of teenage friends, their mishaps, and their coming of age, set in 1970s Wisconsin.
- CreatorBill LawrenceStarsZach BraffDonald FaisonSarah ChalkeIn the unreal world of Sacred Heart Hospital, intern John "J.D." Dorian learns the ways of medicine, friendship and life.
- CreatorRob McElhenneyGlenn HowertonStarsCharlie DayGlenn HowertonRob McElhenneyFive friends with big egos and small brains are the proprietors of an Irish pub in Philadelphia.
- CreatorLiz BrixiusEvan DunskyLinda WallemStarsEdie FalcoMerritt WeverPaul SchulzeA drug-addicted nurse struggles to find a balance between the demands of her frenetic job at a New York City hospital and an array of personal dramas.
- CreatorDarren StarStarsSarah Jessica ParkerKim CattrallKristin DavisFour female New Yorkers gossip about their sex lives (or lack thereof) and find new ways to deal with being a woman in the late 1990s.
- CreatorPaul AbbottJohn WellsStarsEmmy RossumWilliam H. MacyEthan CutkoskyA scrappy, feisty, fiercely loyal Chicago family makes no apologies.
- CreatorMichael JacobsApril KellyStarsBen SavageRider StrongWilliam DanielsAn adolescent with two siblings tests his various theories about life as he endures the trials of growing up alongside a good friend.
- CreatorJames Manos Jr.StarsMichael C. HallJennifer CarpenterDavid ZayasHe's smart. He's lovable. He's Dexter Morgan, America's favorite serial killer, who spends his days solving crimes and nights committing them.
- CreatorJ.J. AbramsJeffrey LieberDamon LindelofStarsJorge GarciaJosh HollowayYunjin KimThe survivors of a plane crash are forced to work together in order to survive on a seemingly deserted tropical island.
- CreatorStephanie SavageJosh SchwartzStarsBlake LivelyLeighton MeesterPenn BadgleyPrivileged teens living on the Upper East Side of New York can hide no secret from the ruthless blogger who is always watching.
- CreatorShonda RhimesStarsEllen PompeoChandra WilsonJames Pickens Jr.A drama centered on the personal and professional lives of five surgical interns and their supervisors.
- CreatorAlan BallStarsAnna PaquinStephen MoyerSam TrammellTelepathic waitress Sookie Stackhouse encounters a strange new supernatural world when she meets the mysterious Bill Compton, a southern Louisiana gentleman and vampire.
- CreatorCarter BaysCraig ThomasStarsJosh RadnorJason SegelCobie SmuldersA father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- CreatorTerence WinterStarsSteve BuscemiKelly MacdonaldMichael ShannonAn Atlantic City politician plays both sides of the law by conspiring with gangsters during the Prohibition era.
- CreatorJ.J. AbramsAlex KurtzmanRoberto OrciStarsAnna TorvJoshua JacksonJohn NobleAn F.B.I. agent is forced to work with an institutionalized scientist and his son in order to rationalize a brewing storm of unexplained phenomena.
- CreatorRon CowenDaniel LipmanRussell T. DaviesStarsGale HaroldHal SparksRandy HarrisonBrash humor and genuine emotion make up this series revolving around the lives, loves, ambitions, careers and friendships of a group of gay men and women living on Liberty Avenue in contemporary Pittsburgh, PA.
- CreatorIan BrennanBrad FalchukRyan MurphyStarsLea MicheleJane LynchMatthew MorrisonA group of ambitious misfits try to escape the harsh realities of high school by joining a glee club headed by a passionate Spanish teacher.
- CreatorVince GilliganStarsBryan CranstonAaron PaulAnna GunnA chemistry teacher diagnosed with inoperable lung cancer turns to manufacturing and selling methamphetamine with a former student in order to secure his family's future.
- CreatorAlan BallStarsPeter KrauseMichael C. HallFrances ConroyA chronicle of the lives of a dysfunctional family who run an independent funeral home in Los Angeles.
- CreatorDavid CaspeStarsEliza CoupeElisha CuthbertZachary KnightonThis Chicago-set sitcom follows the intertwined lives of six young urbanites trying to learn the ropes of adulthood. Through breakups and whatever other curve-balls life throws them, the pals stick together.
- CreatorRyan MurphyStarsDylan WalshJulian McMahonJoely RichardsonTwo plastic surgeons--one a dedicated family man and one an unscrupulous playboy--strive to maintain their business whilst having to work their way through numerous hardships ranging from personal to clients with criminal connections.
- CreatorJosh SchwartzStarsMischa BartonAdam BrodyPeter GallagherA troubled youth becomes embroiled in the lives of a close-knit group of people in the wealthy, upper-class neighborhood of Newport Beach, Orange County, California.
- CreatorMark SchwahnStarsChad Michael MurrayJames LaffertyHilarie Burton MorganHalf-brothers Lucas and Nathan Scott trade between kinship and rivalry both on the basketball court and in the hearts of their friends in the small, but not so quiet town of Tree Hill, North Carolina.
- CreatorKevin WilliamsonStarsJames Van Der BeekKatie HolmesMichelle WilliamsTwo childhood best friends, Dawson and Joey, go through different stages of adolescence together. Their friendship is later tested when they both start a relationship with different people.
- CreatorMarc CherryStarsTeri HatcherFelicity HuffmanMarcia CrossSecrets and truths unfold through the lives of female friends in one suburban neighborhood after the mysterious suicide of a neighbor.
- CreatorJon Robin BaitzStarsDave AnnableCalista FlockhartRachel GriffithsThe story of the drama surrounding a family's adult siblings.
- CreatorCecelia AhernDonald ToddStarsChristina ApplegateJennifer EspositoKevin DunnA woman suffers from amnesia and is forced to find out who she really is.
- CreatorI. Marlene KingStarsTroian BellisarioAshley BensonLucy HaleFour friends band together against an anonymous foe who threatens to reveal their darkest secrets, while also investigating the disappearance of their best friend.
- CreatorMichael Patrick KingLisa KudrowStarsLisa KudrowLance BarberRobert Michael MorrisAn ex A-list celebrity attempts to rekindle the flame of her once prominent acting career with nothing but a camera crew and some determination.
- CreatorGregory Thomas GarciaStarsLucas NeffMartha PlimptonGarret DillahuntJimmy becomes a single parent to an infant after her mother, with whom he had a one-night stand, ends up on Death Row.