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- DirectorBryan SingerStarsHugh LaurieLisa EdelsteinOmar EppsYoung kindergarten teacher Rebecca Adler collapses in her classroom after losing intelligible speech while teaching students.
- DirectorPeter O'FallonStarsHugh LaurieLisa EdelsteinOmar EppsThe team helps a high school boy (16) who has double vision and night terrors. (Clinic Cases: Unvaccinated baby, man with boil on leg.)
- DirectorBryan SingerStarsHugh LaurieLisa EdelsteinOmar EppsA college boy whose low blood pressure does not respond with IV fluids piques House's curiosity. Clinic Cases: A woman who had a cold last week, man with a sore throat, woman whose leg hurts after running 6 miles, a boy and his MP3 Player.
- DirectorNewton Thomas SigelStarsHugh LaurieLisa EdelsteinOmar EppsA nightmare scenario hits Princeton Plainsboro when babies in the maternity ward are hit by a potentially fatal epidemic. Clinic Cases: Woman with a parasite!
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsA nun suffering from acute dermatitis and asthma treated by House with possibly the wrong medication comes dangerously close to death.
- DirectorPeter MedakStarsHugh LaurieLisa EdelsteinOmar EppsA 38-year-old mother, apparently suffering from thrombosis, alcoholism and schizophrenia, has only her young son as caregiver.
- DirectorBryan SpicerStarsHugh LaurieLisa EdelsteinOmar EppsA woman comes down with symptoms of African sleeping sickness, but there seems to be no way she could have contracted it. House and his aides must ask a few tough questions and make some tough decisions in order to try to save her.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsHouse treats a patient on death row while Dr. Cameron avoids telling a patient she has a terminal illness.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA very brave and mature 9-year-old girl has terminal cancer, but that is not what the problem seems to be.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsCuddy joins the team after her handyman falls off of her roof and begins to develop bizarre symptoms. Clinic Cases: African American man who objects to "minority meds."
- DirectorPeter O'FallonStarsHugh LaurieLisa EdelsteinOmar EppsA doctor campaigns against the epidemic of TB in Africa, possibly at the risk of his own life.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsThe team takes care of a student with inexplicable electrical shocks, and House's parents visit.
- DirectorFred GerberStarsHugh LaurieLisa EdelsteinOmar EppsStar bicycle racer collapses, and the team must come up with a diagnosis after the patient admits to blood doping. House and Stacy continue sparring with each other. Clinic Case: Flight attendant poisons himself with gum.
- DirectorGloria MuzioStarsHugh LaurieLisa EdelsteinOmar EppsAfter being accused of assaulting a sick man, House is forced to take on his case. However, despite the fact that he has AIDS, it's clearly not what's killing him.
- DirectorDavid SemelStarsHugh LaurieLisa EdelsteinOmar EppsChaos ensues after Chase's negligence leads to the death of a female patient. Now, after an inquiry from the hospital board, and a subpoena from the patient's brother, it's up to Stacey to protect Chase's career, as well as House's.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA woman collapses at an off-track betting parlor in front of House, and he must battle his new boss to find her diagnosis.
- DirectorJace AlexanderStarsHugh LaurieLisa EdelsteinOmar EppsWhen a famous writer is brought in with language difficulties, House must assist via phone while waiting for a delayed plane.
- DirectorDavid SemelStarsHugh LaurieLisa EdelsteinOmar EppsHouse and the team must determine what is causing an increasingly deceitful patient's muscle flailing. Stacy makes a decision, and Cameron avoids a test.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsA patient with 40% body burns and inexplicable cardiac and neurological signs is treated by the team, while House pursues disproving an old enemy's medical study.
- DirectorJames HaymanStarsHugh LaurieLisa EdelsteinOmar EppsThe search for the cause of a supermodel's symptoms causes intense feelings among the team, as new facts are revealed. Meanwhile, House experiences increasing pain in his leg.
- DirectorDavid SemelStarsHugh LaurieLisa EdelsteinOmar EppsHouse and the team struggle to diagnose one patient in order to save another. Clinic Case: College student claims he has the hots for heifers.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsHouse must diagnose a man who became sick and experienced difficulty breathing during sex-play but all tests keep returning normal. Wilson experiences close-up what living with House is like. Clinic case: Herpes
- DirectorFélix Enríquez AlcaláStarsHugh LaurieLisa EdelsteinOmar Epps6 months after a teenage girl crushes her chest in a car accident and receives a heart transplant she goes into anaphylactic shock in her clean bedroom after her boyfriend almost kisses her and discovers something on her arm.
- DirectorFred GerberStarsHugh LaurieLisa EdelsteinOmar EppsOn a class field trip, a teacher discovers that her six-year-old student, Ian, is bleeding profusely. Dr. House thinks Ian has the same unknown disease that killed an elderly patient of his years ago.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsCameron gets mad at Foreman because Foreman steals his idea for an article. The case of the week: a lesbian woman has not slept for ten days despite taking a bottle of sleeping pills.
- DirectorJohn F. ShowalterStarsHugh LaurieLisa EdelsteinOmar EppsHouse takes on a teenage faith healer, Wilson desperately wants into a poker game, and tensions escalate between Cameron and Foreman.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA police officer in critical condition has bizarre symptoms, and Dr. Foreman finds himself in an unpleasant situation.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsHouse tries radical procedures to save Foreman's life; Foreman's father visits.
- DirectorDaniel SackheimStarsHugh LaurieLisa EdelsteinOmar EppsA dad kisses his wife and baby goodbye before leaving for work, pukes and returns to find his wife with seizure in the bathtub and the baby under water. Foreman is back but changed.
- DirectorMartha MitchellStarsHugh LaurieLisa EdelsteinOmar EppsHouse cares for a young Katrina victim, the alleged daughter of an old friend of his. He supposes she has hallucinations because of the heart, but it turns out not to be the cause. House discovers a disease that her grandfather had.
- DirectorDavid ShoreStarsHugh LaurieLisa EdelsteinOmar EppsAn old patient of House comes back and seeks revenge upon him in the form of gunshot.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsHouse's preoccupation with Wilson leaves his team without direction and endangers the patient, a female whose exhaustive work schedule and demanding boss may have caused her condition.
- DirectorDavid StraitonStarsHugh LaurieLisa EdelsteinOmar EppsYears after receiving body parts from an organ donor, five out of six recipients die within a few months, but not from organ rejection. House and the team race against time to figure out why before the final surviving recipient, a young woman who received the donor's cornea, mysteriously dies as well. House retains a comical private investigator to investigate patients, doctors, and his estranged friend, Wilson.
- DirectorAndrew BernsteinStarsHugh LaurieLisa EdelsteinOmar EppsHouse's investigator gets information on everyone, which House uses to stir the pot of their lives while the team tries to cure a portraitist whose artistic view now looks like Picasso.
- DirectorDavid PlattStarsHugh LaurieLisa EdelsteinOmar EppsHouse tries every delaying tactic available when Wilson forces him to attend his father's funeral. Meanwhile, the team tries to find the cause of a young woman's abdominal pain and hemorrhage that occurred in China.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsThirteen's one night stand collapses at her apartment, and her symptoms are so misleading that the diagnosis may be terminal. Meanwhile, revelation about Wilson and Thirteen occupy House.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsHouse takes on a case where the patient has unexplained blackouts, and his daughter may hold the key to the diagnosis. Meanwhile, Cuddy prepares for her new arrival until there are complications with the birth mother.