The quirky spin on Conan Doyle's iconic sleuth pitches him as a "high-functioning sociopath" in modern-day London. Assisting him in his investigations: Afghanistan War vet John Watson, who's introduced to Holmes by a mutual acquaintance.
A woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
When a psychopath commits murders based on novelist Castle's books, Detective Beckett seeks his help to solve the case. He decides to work with her and uses his experiences as research for his novels.