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- CreatorDavid ShoreStarsHugh LaurieOmar EppsRobert Sean LeonardUsing a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- CreatorMarc CherryStarsTeri HatcherFelicity HuffmanMarcia CrossSecrets and truths unfold through the lives of female friends in one suburban neighborhood after the mysterious suicide of a neighbor.
- CreatorTim KringStarsJack ColemanHayden PanettiereMilo VentimigliaCommon people discover that they have super powers. Their lives intertwine as a devastating event must be prevented.
- CreatorDavid CaspeStarsEliza CoupeElisha CuthbertZachary KnightonThis Chicago-set sitcom follows the intertwined lives of six young urbanites trying to learn the ropes of adulthood. Through breakups and whatever other curve-balls life throws them, the pals stick together.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorLarry DavidJerry SeinfeldStarsJerry SeinfeldJulia Louis-DreyfusMichael RichardsThe continuing misadventures of neurotic New York City stand-up comedian Jerry Seinfeld and his equally neurotic New York City friends.
- CreatorJames Manos Jr.StarsMichael C. HallJennifer CarpenterDavid ZayasHe's smart. He's lovable. He's Dexter Morgan, America's favorite serial killer, who spends his days solving crimes and nights committing them.
- CreatorKari LizerStarsJulia Louis-DreyfusClark GreggHamish LinklaterA divorced mom tries to keep pace with everyone around her.
- CreatorGreg DanielsRicky GervaisStephen MerchantStarsSteve CarellJenna FischerJohn KrasinskiA mockumentary on a group of typical office workers, where the workday consists of ego clashes, inappropriate behavior, tedium and romance.
- CreatorJ.J. AbramsMatt ReevesStarsKeri RussellScott SpeedmanScott FoleyA young girl, fresh out of high school, follows her high school crush to college to be near him.
- CreatorBill LawrenceStarsZach BraffDonald FaisonSarah ChalkeIn the unreal world of Sacred Heart Hospital, intern John "J.D." Dorian learns the ways of medicine, friendship and life.
- CreatorPaul T. ScheuringStarsDominic PurcellWentworth MillerAmaury NolascoA structural engineer installs himself in a prison he helped design, in order to save his falsely accused brother from a death sentence by breaking themselves out from the inside.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoA woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- CreatorCarter BaysCraig ThomasStarsJosh RadnorJason SegelCobie SmuldersA father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- CreatorSteven LevitanChristopher LloydStarsEd O'NeillSofía VergaraJulie BowenThree different, but related, families face trials and tribulations in their own uniquely comedic ways.
- CreatorEileen HeislerDeAnn HelineStarsPatricia HeatonNeil FlynnCharlie McDermottThe daily mishaps of a married woman and her semi-dysfunctional family and their attempts to survive life in general in the town of Orson, Indiana.
- CreatorEmily KapnekStarsJeremy SistoJane LevyCarly ChaikinTessa Altman is used to the big city, but when her dad moves her away, she has to adapt to her new suburban life in Chatswin.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorSam BobrickStarsMark-Paul GosselaarMario LopezDustin DiamondA close-knit group of six friends get through their teens together while attending Bayside High School in Palisades, California.
- CreatorKevin BiegelBill LawrenceStarsCourteney CoxChrista MillerBusy PhilippsFollows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.
- CreatorAmy Sherman-PalladinoStarsLauren GrahamAlexis BledelKeiko AgenaA dramedy centering around the relationship between a thirtysomething single mother and her teen daughter living in Stars Hollow, Connecticut.
- CreatorBrenda HamptonStarsStephen CollinsCatherine HicksJessica BielEric Camden, a minister, and his wife Annie deal with the drama of having seven children, ranging from toddlers to adults with families of their own.
- CreatorTom HertzStarsPatrick WarburtonMegyn PriceOliver HudsonTwo couples and their single friend, all at different stages in their relationships, deal with the complications of dating, commitment, and marriage.
- CreatorSamuel BaumStarsTim RothKelli WilliamsBrendan HinesAbout Cal Lightman, the world's leading deception expert who studies facial expressions and involuntary body language to expose the truth behind the lies.
- CreatorPhil RosenthalStarsRay RomanoPatricia HeatonBrad GarrettThe comical everyday life of sports columnist Ray Barone and his dysfunctional family.
- CreatorRoseanne BarrMatt WilliamsStarsRoseanne BarrJohn GoodmanLaurie MetcalfA revival of the popular 1990s sitcom "Roseanne," which centered on the everyday life of an American working-class family.
- CreatorRichard LevinsonWilliam LinkStarsPeter FalkMike LallyJohn FinneganLos Angeles homicide detective Lieutenant Columbo uses his humble ways and ingenuous demeanor to winkle out even the most well-concealed of crimes.
- CreatorAndy BreckmanStarsTony ShalhoubJason Gray-StanfordTed LevineThe series follows Adrian Monk, a brilliant former San Francisco detective, who now consults the police as a private consultant whilst battling with an obsessive-compulsive disorder.
- CreatorLee Phillip BellWilliam J. BellStarsEric BraedenDoug DavidsonPeter BergmanSet in Genoa City, this is the long-running soap that tells the story of the struggle behind the business, and sex-savvy Abbott and Newman clans.
- CreatorClaudia LonowStarsJenna ElfmanJon FosterAshley Jensen37-year-old Billie breaks up with her boss at the newspaper and gets pregnant by 22-year-old Zack, who moves into her apartment. They both have their pals.
- CreatorJohn GrayStarsJennifer Love HewittDavid ConradCamryn ManheimMelinda Gordon, a newly married woman, possesses the gift of communicating with the dead. With her best friend Andrea's assistance, she helps the earthbound spirits to find peace and cross over.
- CreatorJoss WhedonStarsSarah Michelle GellarNicholas BrendonAlyson HanniganA young woman, destined to slay vampires, demons and other infernal creatures, deals with her life fighting evil, with the help of her friends.
- CreatorFran DrescherPrudence FraserPeter Marc JacobsonStarsFran DrescherCharles ShaughnessyDaniel DavisAfter being fired from her job and dumped by her boyfriend, a cosmetics saleswoman becomes the nanny to the three children of a rich English widower. As time passes, the two fall for each other.
- CreatorDarren StarStarsJason PriestleyShannen DohertyLuke PerryA group of friends living in Beverly Hills, California make their way through life from their school days into adulthood.
- CreatorAli LeRoiChris RockStarsTerry CrewsTichina ArnoldTequan RichmondA young African-American teen attempts to survive with his dysfunctional family and his all-white school in the 1980s.
- CreatorWil CalhounDan SchneiderStarsAmanda BynesJennie GarthWesley JonathanWhen Holly's father is transferred to Japan, she is sent to live with her big sister Valerie in New York City, turning Valerie's life upside down.
- CreatorWilliam J. BellLee Phillip BellStarsKatherine Kelly LangRonn MossJohn McCookThe saga of high fashion glamour, honor, romance, passion, and most importantly, family.
- CreatorRon LeavittMichael G. MoyeStarsEd O'NeillChristina ApplegateKatey SagalAl is the quintessential working class dad. Peggy, his wife, always wants more from him. With their children, they go through the highs and lows of ordinary life.
- CreatorJosh GoldsmithCathy YuspaStarsBrad GarrettJoely FisherKat FosterNewlyweds move in next door to a veteran married couple of 25 years.
- CreatorEd YeagerStarsJay MohrPaula MarshallRyan MalgariniNewly divorced after fifteen years of marriage, Gary Brooks, a painting contractor, strives to balance work, shared custody of his two children, a controlling ex-wife, and his foxy new girlfriend.