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- DirectorAntonio NaharroÁlvaro PastorStarsLola DueñasPablo PinedaIsabel García LorcaDaniel - a recent university graduate with Down's Syndrome - falls in love on his first day at work in the Department of Social Services. Laura is an outsider who spends her nights in the city's crowded clubs and singles' bars, escaping her problems in the arms of total strangers. Yet despite their apparent incompatibility, the two strike up a moving, bittersweet friendship that touches them both and eventually sets them on the road to happiness.
- DirectorJim SheridanStarsDaniel Day-LewisBrenda FrickerAlison WhelanChristy Brown, born with cerebral palsy, learns to paint and write with his only controllable limb - his left foot.
- DirectorDamien O'DonnellStarsJames McAvoySteven RobertsonRomola GaraiWhen the kinetic Rory moves into his room in the Carrigmore Residential Home for the Disabled, his effect on the home is immediate. Most telling is his friendship with Michael, a young man with cerebral palsy and nearly unintelligible speech. Somehow, Rory understands Michael, and encourages him to experience life outside the confines of home.
- DirectorOlivier NakacheÉric ToledanoStarsFrançois CluzetOmar SyAnne Le NyAfter he becomes a quadriplegic from a paragliding accident, an aristocrat hires a young man from the projects to be his caregiver.
- DirectorDanny BoyleStarsJames FrancoAmber TamblynKate MaraA mountain climber becomes trapped under a boulder while canyoneering alone near Moab, Utah and resorts to desperate measures in order to survive.
- DirectorTyler NilsonMichael SchwartzStarsZack GottsagenAnn PierceDakota JohnsonZak, a man with down syndrome, runs away from a residential nursing home to pursue his dream of becoming a wrestler. Later, he meets with an outlaw who becomes his friend and coach.
- DirectorDavid LynchStarsAnthony HopkinsJohn HurtAnne BancroftA Victorian surgeon rescues a heavily disfigured man who is mistreated while scraping a living as a side-show freak. Behind his monstrous façade, there is revealed a person of kindness, intelligence and sophistication.
- DirectorJulian SchnabelStarsMathieu AmalricEmmanuelle SeignerMarie-Josée CrozeThe true story of Elle editor Jean-Dominique Bauby who suffers a stroke and has to live with an almost totally paralyzed body; only his left eye isn't paralyzed.
- DirectorHans-Christian SchmidStarsRobert StadloberTom SchillingOona-Devi Liebich16 year old, paralyzed Benjamin switches to a boarding school to get better grades where he has to struggle with the various problems of coming of age: He falls in love with the school's dream girl Malen.
- DirectorMohsen MakhmalbafStarsNelofer PaziraHassan TantaiIke OgutAfter an Afghanistan-born woman who lives in Canada receives a letter from her suicidal sister, she takes a perilous journey through Afghanistan to try to find her.
- DirectorDavid FincherStarsBrad PittCate BlanchettTilda SwintonTells the story of Benjamin Button, a man who starts aging backwards with consequences.
- DirectorTaylor HackfordStarsJamie FoxxRegina KingKerry WashingtonThe story of the life and career of the legendary rhythm and blues musician Ray Charles, from his humble beginnings in the South, where he went blind at age seven, to his meteoric rise to stardom during the 1950s and 1960s.
- DirectorRon HowardStarsRussell CroweEd HarrisJennifer ConnellyA mathematical genius, John Nash made an astonishing discovery early in his career and stood on the brink of international acclaim. But the handsome and arrogant Nash soon found himself on a harrowing journey of self-discovery.
- DirectorChris WaittStarsAleksandra BoyarskayaDanielle McLeodOlivia TrenchA humorous look at life for a loser in love.
- DirectorVincente MinnelliGeorge CukorStarsKirk DouglasAnthony QuinnJames DonaldThe life of brilliant but tortured artist Vincent van Gogh.
- DirectorMathieu KassovitzStarsHalle BerryPenélope CruzRobert Downey Jr.A psychiatrist awakens as a patient in a mental institution, with no memory of the murder she's accused of committing. As she tries to regain her memory, a vengeful spirit manipulates her.
- DirectorJames MarshStarsEddie RedmayneFelicity JonesTom PriorStephen Hawking gets unprecedented success in the field of physics despite being diagnosed with motor neuron disease at the age of 21. He defeats awful odds as his first wife Jane aids him loyally.
- DirectorMilos FormanStarsJack NicholsonLouise FletcherMichael BerrymanIn the Fall of 1963, a Korean War veteran and criminal pleads insanity and is admitted to a mental institution, where he rallies up the scared patients against the tyrannical nurse.
- DirectorMartin BrestStarsAl PacinoChris O'DonnellJames RebhornA prep school student needing money agrees to "babysit" a blind man, but the job is not at all what he anticipated.
- DirectorTodd PhillipsStarsJoaquin PhoenixRobert De NiroZazie BeetzDuring the 1980s, a failed stand-up comedian is driven insane and turns to a life of crime and chaos in Gotham City while becoming an infamous psychopathic crime figure.
- DirectorGuillermo del ToroStarsSally HawkinsOctavia SpencerMichael ShannonAt a top secret research facility in the 1960s, a lonely janitor forms a unique relationship with an amphibious creature that is being held in captivity.
- DirectorLuis BuñuelStarsCatherine DeneuveFernando ReyFranco NeroShortly after her mother's death, an innocent and youthful woman will find refuge into the household of her middle-aged aristocratic guardian, who will submit her to his sexual advances.
- DirectorRogelio A. GonzálezStarsArturo de CórdovaAmparo RivellesElda PeraltaA taxidermist decides to murder his wife after having to put up with her after fifteen years of hellish marriage.
- DirectorJohn SchlesingerStarsDustin HoffmanJon VoightSylvia MilesA naive hustler travels from Texas to New York City to seek personal fortune, finding a new friend in the process.
- DirectorWes AndersonStarsLuke WilsonOwen WilsonNed DowdThree friends plan to pull off a simple robbery and go on the run.
- DirectorSian HederStarsEmilia JonesMarlee MatlinTroy KotsurAs a CODA (Child of Deaf Adults) Ruby is the only hearing person in her deaf family. When the family's fishing business is threatened, Ruby finds herself torn between pursuing her passion at Berklee College of Music and her fear of abandoning her parents.
- DirectorRobert AldrichStarsBette DavisJoan CrawfordVictor BuonoA former child star torments her paraplegic sister in their decaying Hollywood mansion.
- DirectorTom HooperStarsColin FirthGeoffrey RushHelena Bonham CarterThe story of King George VI, his unexpected ascension to the throne of the British Empire in 1936, and the speech therapist who helped the unsure monarch overcome his stammer.
- DirectorDavid LynchStarsJack NanceCharlotte StewartAllen JosephHenry Spencer tries to survive his industrial environment, his angry girlfriend, and the unbearable screams of his newly born mutant child.
- DirectorVolker SchlöndorffStarsDavid BennentMario AdorfAngela WinklerIn 1924, Oskar Matzerath is born in the Free City of Danzig. At age three, he falls down a flight of stairs and stops growing. In 1939, World War II breaks out.
- DirectorTod BrowningStarsWallace FordLeila HyamsOlga BaclanovaA circus' beautiful trapeze artist agrees to marry the leader of side-show performers, but his deformed friends discover she is only marrying him for his inheritance.
- DirectorBarry LevinsonStarsDustin HoffmanTom CruiseValeria GolinoAfter a selfish L.A. yuppie learns his estranged father left a fortune to an autistic-savant brother in Ohio that he didn't know existed, he absconds with his brother and sets out across the country, hoping to gain a larger inheritance.
- DirectorRobert ZemeckisStarsTom HanksRobin WrightGary SiniseThe history of the United States from the 1950s to the '70s unfolds from the perspective of an Alabama man with an IQ of 75, who yearns to be reunited with his childhood sweetheart.
- DirectorAisling WalshStarsSally HawkinsEthan HawkeZachary BennettAn arthritic Nova Scotia woman works as a housekeeper while she hones her skills as an artist and eventually becomes a beloved figure in the community.