After cheating death, master criminal Dr. Fu Manchu returns with a plot to contaminate the River Thames with a powerful toxin extracted from Tibetan poppies.
To foil a terrorist plot, FBI agent Sean Archer assumes the identity of the criminal Castor Troy who murdered his son through facial transplant surgery, but the crook wakes up prematurely and vows revenge.
A pair of NYPD detectives in the Narcotics Bureau stumble onto a heroin smuggling ring based in Marseilles, but stopping them and capturing their leaders proves an elusive goal.