Shortly after the defeat of Doctor Octopus and his symbiont army from the previous game, super-villain Electro attacks New York using high powered weaponry that'll turn him into a god, leaving Spider-Man to save the day.
Peter Parker promises Mary Jane to get a bowl for her goldfish, but gets involved in stopping a crimewave as Spider-Man - Hammerhead, the Big Wheel, Electro, the Rhino and the Scorpion are causing chaos in New York City, in a grand scheme devised by criminal mastermind Mysterio.