- Is best friends with The Office (2005) co-star Angela Kinsey and is godmother to Kinsey's daughter, Isabel.
- Worked as a receptionist in various offices. Types 85 wpm with 90% accuracy.
- Fractured her back in four places after falling down a set of stairs at the NYC bar Buddakan on May 15, 2007.
- Auditioned for the role of Sydney Bristow in Alias (2001) but was never called back. She later said, "They said they liked my acting, but I wasn't hot enough.".
- Took her first acting class with Sean Gunn (who stars as Kirk on WB's Gilmore Girls (2000)) at the age of six in St. Louis, Missouri. The class was taught by her mother, Anne Fischer. Jenna and Sean stayed in touch over the years and in October 2000 she married his brother, writer/director James Gunn. The two are now divorced.
- Considered becoming a veterinarian because of her love for animals but ultimately opted for working with Kitten Rescue and being the proud owner of a dog and a cat (Andy, featured prominently with Jenna in 2006 issue of People Magazine's 100 Most Beautiful).
- She confirmed in an interview that she was fired after appearing in the series pilot of Man with a Plan (2016) playing the wife of Matt LeBlanc's character. She said that the preview audience couldn't believe that "Pam" was married to "Joey", referring to their most famous characters from other shows. The role was recast and Liza Snyder got the part.
- Gave birth to her 1st child at age 37, a son Weston Lee Kirk on September 24, 2011. Child's father is her 2nd husband, Lee Kirk.
- Purchased a $1.9m luxury home in the Glendale area of L.A., an estate that had once belonged to legendary baseball player, coach, and manager Casey Stengel. (2012)
- Originally enrolled at Truman State University as a pre-law student; later changed her major to theatre.
- Before becoming an actress, Jenna worked for 3 years at a car wash and also briefly tried her hand at being a telephone psychic when she first moved to L.A.
- Was #37 in People Magazine's 100 Most Beautiful list, 2006 issue.
- Gave birth to her second child at age 40, daughter Harper Marie Kirk, on May 25, 2014. Child's father is her second husband, Lee Kirk.
- Graduated from Truman State University in Kirksville, Missouri.
- She and her ex-husband James Gunn remain close friends.
- Went to Nerinx Hall High School, an all-girls Catholic high school in Webster Groves, Missouri. Another alumnus is Marsha Mason.
- Mother Anne Fischer and younger sister Emily Fischer are both elementary school teachers.
- Along with her co-stars Owen Wilson, Christina Applegate and Alyssa Milano, Fischer is one of 4 actors from the film Hall Pass (2011) to become a first-time parent the same year the film was released.
- Has one sibling, Emily Fischer, her younger sister.
- Got engaged to Lee Kirk on June 30, 2009.
- First met ex-husband James Gunn at a script reading for The Specials (2000), which he wrote.
- Daughter of Anne Fischer.
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