- She is a friend of Fran Drescher and it was Drescher's interaction with Twiggy's children that was used as the basis for Drescher's hit show The Nanny (1993).
- Appeared with David Bowie on the cover of his "Pin Ups" album, and is mentioned in his song "Drive in Saturday" from his Aladdin Sane album.
- Her first marriage, to American actor, Michael Witney, ended with his sudden death from a heart attack.
- She credits Jean Shrimpton as her greatest idol and considers her the world's first supermodel.
- Was regarded as "the face of 1966" in swinging London and gained her nickname from her stick-thin pubescent figure.
- Gave birth to her only child at age 29, a daughter Carly Witney on December 1, 1978. Child's father was her first husband, Michael Witney.
- Attended Cynthia Lennon's wedding to Roberto Bassanini.
- She was the youngest person to ever be surprised by the Big Red Book on This Is Your Life (1955) , aged 19 at the time.
- Has one granddaughter, Joni (b. May 2016), via daughter Carly and her husband, Ben Wiggins.
- Is an accomplished singer and theater star.
- Met her second husband Leigh Lawson on the set of Madame Sousatzka (1988) in 1988.
- Is an avid supporter of animal rights organizations and breast cancer research groups.
- Became pregnant by her first husband Michael Witney but suffered a miscarriage in January 1978 at two months pregnant.
- She was awarded the Dame Commander of the Order of the British Empire in the 2019 Queen's New Years Honours List for her services to Fashion, Arts and Charity in London, England.
- Was nominated for Broadway's 1983 Tony Award as Best Actress (Musical) for "My One and Only."
- Was named "The Face of 1966" by the Daily Express.
- Started a clothing line through Great Universal called the Twiggy Collection for spring/summer 2006.
- Made her return to modeling by fronting a major new TV, press and billboard campaign for Marks & Spencer, the chain department store of the UK. Her appearance alongside Erin O'Connor, Laura Bailey and other younger models is intended to portray the wide variety of choices of the M&S clothing range, as well as the fact that older women are equally entitled to look good.
- Her manager was Justin de Villeneuve.who changed her name and became her manager/boyfriend, launched her to fame and were together for 9 years.
- Youngest daughter of Norman Hornby (a carpenter on Planet Patrol (1963)) and his wife Nell Hornby (née Nellie Lydia Reeman).
- Has a sister Shirley who is 15 years older.
- Model/actress
- Tried out for Romeo and Juliet (1968) but failed to pass the audition.
- Dated Warren Beatty.
- Was ranked #9 in Channel 5's "World's greatest supermodel."
- Delivered her daughter Carly naturally with an epidural and breastfed her for six weeks.
- Is one of 23 actresses who did not receive an Oscar nomination for their Best Actress in a Comedy/Musical Golden Globe-winning performance; hers being for The Boy Friend (1971). The others, in chronological order, are: June Allyson for Too Young to Kiss (1951), Ethel Merman for Call Me Madam (1953), Jean Simmons for Guys and Dolls (1955), Taina Elg and Kay Kendall for Les Girls (1957), Marilyn Monroe for Some Like It Hot (1959), Rosalind Russell for A Majority of One (1961) and Gypsy (1962), Patty Duke for Me, Natalie (1969), Raquel Welch for The Three Musketeers (1973), Barbra Streisand for A Star Is Born (1976), Bernadette Peters for Pennies from Heaven (1981), Kathleen Turner for Romancing the Stone (1984) and Prizzi's Honor (1985), Miranda Richardson for Enchanted April (1991), Jamie Lee Curtis for True Lies (1994), Nicole Kidman for To Die For (1995), Madonna for Evita (1996), Renée Zellweger for Nurse Betty (2000), Sally Hawkins for Happy-Go-Lucky (2008), Amy Adams for Big Eyes (2014), Awkwafina for The Farewell (2019), Rosamund Pike for I Care a Lot (2020) and Rachel Zegler for West Side Story (2021).
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