- He enjoyed working with Stan Laurel and felt he learned a lot from him about the construction of gags.
- Three days before his death he was inducted into the Academy of Motion Picture Arts and Sciences Hall of Fame.
- He is one of the few directors to direct two versions of the same story, Destry Rides Again (1939) and Destry (1954). Only the 1939 version is a classic.
- His directing career stretched over 55 years and he continued to direct until he was 80 years of age. His output ranged from silent shorts to episodic television.
- He has directed two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Destry Rides Again (1939) and How the West Was Won (1962).
- From 1948-50 he was President of the Screen Directors Guild.
- Served as a combat cinematographer in the U.S. Army Signal Corps in France during World War I.
- He and Hal Roach (I) were old acquaintances, which was probably why Roach hired him.
- If the situation arose he would play a small part in films. When a bit actor didn't turn up for Pack Up Your Troubles (1932), he put on an apron and played a mess sergeant.
- Children: Germaine Marshall and George Marshall Jr..
- Father-in-law of assistant director Frank Baur.
- Biography in: John Wakeman, editor. "World Film Directors, Volume One, 1890-1945". Pages 731-735. New York: The H.W. Wilson Company, 1987.
- Father: George Elmer Marshall; Mother: Sara Elizabeth Underwood.
- George E. Marshall Jr. (Sound Department) is his grandson.
- Father-in-law of actress Helene Marshall.
- He joined the industry as an extra in 1912.
- He once roomed with Frank Lloyd and William Seiter, two other extras who also became top ranking directors.
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