One of the most successful women screenwriters of her time, Meredyth began as a short story writer for various newspapers. She entered films in 1911 as an extra for
D.W. Griffith at Biograph. She then moved to Hollywood and worked as both actress and a prolific contributor of scenarios. During the 1920's and 30's, she was under contract at most of the major studios, including MGM (1924-25; 1929-33), United Artists (1934-35), Warner Brothers and Columbia. She was famously brought in (along with
Carey Wilson to replace
June Mathis as scenarist for the blockbuster epic,
Ben-Hur: A Tale of the Christ (1925).