- Entered films in 1915 as a stuntman in westerns.
- Was one of the founding members of the Directors Guild
- He is especially remembered for his handling of comedy. In his long career, he made films with Bert Wheeler and Robert Woolsey, The Ritz Brothers, Shirley Temple, W.C. Fields, The Marx Brothers, Stan Laurel and Oliver Hardy and Bud Abbott and Lou Costello.
- Bore a startling resemblance to Oliver Hardy, whom he directed in Sons of the Desert (1933).
- Father of John Henry Seiter (1911-2000).
- Father of Christopher N. Seiter and Jessica Seiter Niblo.
- Grandfather of Stephanie Seiter Blansett.
- Grandfather of Ted Griffin
- In his early days he shared a room with George Marshall and Frank Lloyd.
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