- Began a relationship with Lauren Shippey from age 14 before becoming engaged to her in April 2011. They went on to break up in October 2017 and share custody of their two children.
- Has one brother, Tom and one sister, Amy.
- Jack replaced Thomas Ormson, in the role of "David Platt" on Coronation Street (1960), in 2000, having only begun his acting career the previous year.
- Became a father for the first time at age 21 when his [now ex] girlfriend Lauren Shippey gave birth to their daughter Nyla Rae Shepherd on February 13, 2009.
- Became a father for the third time at age 25 when his [now ex] girlfriend Lauren Shippey gave birth to their son Reuben Shepherd on December 17, 2013.
- Became a father for the second time at age 22 when his one-night stand Sammy Milewski gave birth to their disabled son Greyson Milewski on January 6, 2011. Shepherd has no contact with the child.
- He supports Leeds United football club
- Moved in with co-star Colson Smith following his split from Lauren Shippey.
- Is one of five Coronation Street (1960) actors to have won the Best Actor award at the British Soap Awards; the others are Brian Capron, Antony Cotton, Alan Halsall and David Neilson.
- Has been in a relationship with publicist Hanni Treweek since November 2017 and engaged since June 2018, having proposed whilst on holiday in Greece.
- Had two hair transplants in 2019, after suffering from hair loss for a decade.
- In September 2014 he publicly apologized for making a joke on social media about the Manchester Dogs' Home fire, in which 43 dogs died. Shepherd said he had donated money to the dogs' home as a result of the controversy.
- He has had no contact with his disabled son, despite providing child support.
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