- Has a Croatian background from her father. He moved from Croatia to Venezuela with his parents in 1947
- Gabriela donated the wheelchair she used in the TV series "La Usurpadora" to a worthy cause.
- She has a twin sister, Daniela Spanic who played Gilda in a fight scene of Como tú, ninguna (1994). It was too hard to film the characters of Gilda and Raquel in the same scene, using camera tricks, so the producers contracted Daniela, who is a fashion model, to make this scene "fighting" her real life twin Gabriela, who then, played the part of Raquel. Gabriela revealed this in the Argentinian television show Almorzando con Mirtha Legrand (1968).
- Has a pet snake Cleopatra which she and her twin sister saved from being killed and nursed it back to health.
- She was an original guest on "El Club de Los Tigritos."
- Was Miss Body in the "Miss Venezuela International" (1992)
- Filming "la Venganza" in Colombia (September 2002)
- Gaby Spanic was a student of Marjorie Flores, and a member of "El Ballet de Marjorie Flores."
- On July 7, 2008, she gave birth to her first child, a son named Gabriel de Jesús. Child's father is her ex-boyfriend.
- Has two brothers named Antonio and Adiel and a younger sister named Patricia.
- Filming "La duena de tu amor" (April 2010)
- Filming "Prisionera" in Miami. (November 2003)
- In an episode of Tierra de Pasiones (2006), she punches thirteen times Catherine Siachoque.
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