- His stage name is taken from Keanu Reeves character in The Matrix (1999).
- His mother is Loraine (Parham), who was raised in Bearden, Arkansas. Ne-Yo's maternal grandfather's brother, Bobby Parham, is in the band The Dramatic Force.
- Grew up in Las Vegas.
- Close friends with actor Columbus Short.
- His ex-girlfriend, Monyetta Shaw, gave birth to their first child, Madilyn Grace Smith, on November 12, 2010.
- His ex-fiancé Monyetta Shaw gave birth to their 2nd child a son Mason Evan on Sunday October 9, 2011 weighing 6lbs 10oz.
- Announced that he's engaged and that his fiancée Crystal Renay is expecting a baby [August 31, 2015].
- Has worked with actor Columbus Short twice in two films, Save the Last Dance 2 (2006) and Stomp the Yard (2007)
- Wife Crystal gave birth to their second son, Roman Alexander-Raj Smith on June 14, 2018.
- His wife Crystal gave birth to their son Prince Shaffier Chimere Jr. was Born March 15, 2016.
- Has a godson named Chimere.
- His parents are both African-American. A 23andMe DNA test showed Ne-Yo to be of 88.4% African and 10.1% European genetic descent.
- His wife Crystal gave birth to their daughter Isabella Rose Smith on June 25, 2021.
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