- Often appears alongside his twin brother, Jeffrey Postlethwaite.
- Matthew Postlethwaite is related to The Academy Award nominated (Oscar) Actor Pete Postlethwaite.
- Remained in character throughout the entire production of Shooting Clerks (2019). Various day players and cameo stars were shocked to discover that he wasn't American when filming wrapped.
- Growing up Matthew Postlethwaite always wanted to be an Actor.
- His nickname, 'Old Soul,' refers to a scene from Shooting Clerks (2019) in which his character refers to himself as such. The reason it stuck was that due to a bout of group (cast and crew) corpsing (breaking character by laughing) during filming, Matt had to repeat the line 50 times.
- Matthew Postlethwaite is a BAFTA member and has been noted on their list of extraordinary talent: "BAFTA's ones to watch".
- The closing scene of The Great Artist living through all the different personalities was only filmed once. The production only have five minuets left at the location. The scene was that powerful to watch unfold in person that when Director, Indrani, called 'CUT' every single member of the crew was crying alongside him.
- Matthew is meticulous to his craft.
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