Dustin Hoffman
Raymond Babbitt in "Rain Man"
(Autistic Savant)
Discuss here: http://www.imdb.com/board/bd0000088/flat/232284721
Note 1: This poll does not include roles where actors had a disease, such as Tom Hanks in Philadelphia. It also does not include roles where the actor suffers from drug or alcohol addiction.
Note 2: Watch for the list of actresses also.
Note 3: The words used to describe the handicap or disability of the character are directly from this website. Whether or not they are "politically correct" is unimportant.