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- Chronicles the lives of a group of midwives living in East London in the late 1950s to late 1960s.
- Sister Julienne intervenes in the case of a pregnant prostitute, a family's plan to leave Poplar are up in the air when a mysterious illness strikes, and Sgt. Woolf faces a health crisis of his own.
- In January 1965, a diphtheria outbreak sweeps through Poplar and Mother Mildred seeks to help a distraught woman who abandoned her newborn.
- The plight of a harried matriarch profoundly affects Sister Julienne and Sister Frances, while Sister Hilda helps a nervous expectant father.
- While Martha and Thomas confront Crowley over his strange party and the return of Patricia, Alfred and the lads track down the identity of a wanted killer.