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- When a dozen people die in a cinema fire, Connor is in charge of the investigation. Sam Ryan is coming back to Cambridge.
- Sam Ryan takes on a gangland murder case to help builder Brian McNally, whom she believes to be innocent.
- The team is called out to Northern Ireland to investigate the bodies of two men killed by paramilitaries twenty years ago. For Sam, it is a case that is soon to turn personal.
- In a suspected terrorist attack on a London hotel a government minister is killed. As Sam and the team investigate the case, old friends and government officials soon muddy the water.
- Questions about a celebrated pathologist's accuracy in past cases leads to several exhumations; Sam Ryan is assigned to reexamine the remains. One particularly brutal murder conviction depends on the time of death being precise. Two crucial witnesses are found: one on her deathbed, anxious to get something off her chest, and the other dead behind a remodeled wall.
- The team investigates the derailment of a train caused by someone leaving Maj. Mark Wiltshire's Land Rover on the tracks. The army is suspected but Wiltshire was in the officers mess at the time. The team have yet to identify the 21st victim, or determine if that person was on the train or in the car. Working with a survivor's group, they try to re-create where everyone was seated just prior to the crash occurring. When one of the survivors commits suicide, the crash claims its 22nd victim.
- When a boat carrying illegal passengers is found crashed in the Thames, the team investigate.
- The team follows the trail of the people traffickers, and has to find any remaining survivors before a highly contagious disease breaks.
- The team is called to a drive-by shooting outside a London nightclub. They arrive to a scene of carnage with several people dead, or dying.
- The police may have a serial killer on their hands when they locate a second body in a site where the first victim was found several months before. The body was trussed up in the same way and had an identical burn mark on his back. There is no apparent link between the first victim, student Michael Haughty, and the second Jason Villers, a probationer at the police college. While the police find evidence that may solve the Otty case, they have nothing on the Villers murder. In a separate case, Harry is approached by the wife of an old university friend who asks him to perform a post-mortem on her husband who died in a fall. Harry finds that his old friend was injecting himself regularly. Leo's family is visiting for a few days but he's constantly being called into work.
- Tensions are running high in the 'leaderless' team as Leo and Harry clash over an investigation into an outbreak of breathing difficulties among children on the South Coast.
- Sam Ryan is under great stress when she learns that she may have a tumor. As a result, she starts to question her judgment when she misses a possible explanation in determining the time of death in the case of Lloyd Dupen's wife, an apparent suicide. She's not convinced however that everything is above board and agrees to undertake a second autopsy at the request of the dead woman's mother. She's also asked by Bishop Craig to perform an autopsy on the remains of Sister Constance, a beatified nun who died forty years ago and is under consideration for canonization. The results of the autopsy will have an impact on the religious order as well as many of those in the community who see the commercial advantages of having a local saint.
- Sam comes under intense scrutiny during an official inquiry into the deaths of two brothers while they were in prison. Her findings are soon challenged by her colleague, Leo Dalton, who is brought in to perform a second autopsy. Meanwhile, a series of murders that are taking place cast suspicion on a recently released ex-convict. He served years in prison after being convicted of killing his wife; the evidence against him was given by Sam during one of her very first cases. During his time in prison, however, he continued to deny his guilt. Sam begins to believe that someone is stalking her, while the police have trouble locating the ex-convict.
- The team is shocked when Leo Dalton's wife and daughter are killed when a fancy sports car careens out of control and smashes into a café. The police are puzzled by the cause of the crash but believe the driver may have been involved in a identity theft ring when they find several several passports and ID cards in the vehicle. Meanwhile, Nikki must perform urgent autopsies on two bodies found floating in the river. When she finds fingerprint evidence linking one of the bodies to the car accident, it becomes apparent that the two cases are linked and the police may have been less than forthcoming about their investigation.
- After a helicopter sends out a mayday and disappears in a storm en route to provide support to an off-shore oil rig, Sam is called upon to participate on the rescue team in case it turns into a recovery team.
- The police investigate an apparent break-in that results in the death of Derek Irons, his wife and youngest daughter. Two older children survived the attack but one is in serious condition and in a coma. Irons was a ruthless businessman who targeted his rivals' customers resulting in regular confrontations. Irons was stabbed but his wife and daughter were shot. Sam is reunited with an old friend from Northern Ireland, Det. Supt. Tony Ashton who is the senior investigative officer on the case. Harry assists the police with the death of an old woman who is believed to have fallen down a staircase. His post-mortem reveals evidence that is not consistent with a fall.
- The team investigates two deaths, the first a suicide where someone jumped to their death and the second where a paranoid schizophrenic dressed as a vicar goes on a rampage stabbing innocent bystanders. Their suspicions are aroused when they learn that both men were receiving treatment at the same clinic, January House. Leo assists the police in their investigation of a building society employee who is forcibly taken from his house and subsequently found dead in his own car. Harry is asked to perform an autopsy and provide a second opinion in the death of a young woman. The death was ruled a suicide, but the mother refuses to accept the verdict.
- Harry is called out to a death at a racecourse. A jockey was killed when his horse pulled up and fell, crushing him to death.
- A John Doe is found months after his death; an attractive female agent for a championship athlete is believed to have jumped to her death from a rooftop. Forensic pathologists must sort out time and methods of death.
- When a decomposed body is found hidden in the wall of an old factory building, Sam Ryan concludes he was murdered. He is eventually identified by his ex-girlfriend Selina Thomson as Marcus Saul, who had simply disappeared one day some seven years earlier. There has also been a break-in on campus and drugs have been stolen. The Dean asks Leo Dalton to speak to some of the students on the issue, but he's not quite sure what he can do.
- Sam Ryan assists the police in the investigation of a multi-vehicle collision that results in the death of 11 people. She is joined by two new colleagues: Dr. Leo Dalton, an experienced pathologist from Sheffield and Dr. Harry Cunningham. As they try to determine the causes of the accident, they find a severed arm that does not belong to any of the victims. They also have to deal with DCI Carol Deacon whose role in the investigation is not quite clear to them. Sam and Leo have somewhat different approaches to their job, particularly in how they deal with the police. Harry performs his first autopsy on a child.
- Harry investigates the death of a woman who drowned in a backyard pool. She was apparently struck on the side of the head and her husband claims that her expensive necklace is missing. Leo and Nikki investigate the death of Lucie Philips, a kidnap victim who was taken a week previously. The girl's father tried to pay the ransom but the money was never collected leading the police to believe that the kidnappers may have had other motives. They also investigate the murder of a pizza deliveryman that has similarities with the Philips crime scene. A third murder leads the police to suspect that they may be seeing the work of a serial killer. Nikki's grandmother dies bringing her into contact with her estranged father.
- When twin brothers Jake and Henry Davies are found dead in their home, the police initially suspect robbery as the elderly gentlemen were known to keep large sums of cash in the house. The autopsy reveals murder however and Sam determines that skin grafts both men have on their arms may have been a crude form of plastic surgery meant to cover tattoos of concentration camp numbers. Thinking they are now dealing with a hate crime, the police focus on Carl Martin, a known race-hater. What they have however is a case of someone seeking revenge for the atrocities committed long ago.
- When the naked body of a young woman is found in the snow at a Norwegian ski resort, Sam Ryan is asked to represent the Townsend family whose daughter Ruth disappeared there several weeks before. The autopsy however reveals that it is in fact the body of Louise Hutton who had vanished there some 15 years previously. When Ruth's body is subsequently found, it appears both girls were strangled in a similar fashion. The police focus their enquiries on Ruth's boyfriend and on Henry Hutton, Louise's uncle while Sam seeks the advice of a university colleague and tries to draw a profile of the serial killer.
- Harry investigates a case of hit and run where the victim was a 16 year old boy from the nearby housing estate. Working with Sgt. Susan Fenn, they attempt learn if this was an accident or intentional. Harry takes quite a liking to Susan and is shocked by a sudden turn of event. Leo examines a death resulting from a house fire where the lady of the house died. He is puzzled at why she was unable to leave and the police immediately suspect the husband, who was in a nearby park with the children, of murder. Nikki looks into the case of a young woman who collapses at her hen night. She had recently had minor surgery and was taking pain killers, but there is surprising information to be found about her background.
- The pathologists busy week continues with a variety of cases. Nikki examines a death in a telemarketing office. Several workers were vying for promotion and the police suspect foul play. Harry deals with the case of a professional footballer who committed suicide. He realizes there is a link to another case he is working on. Leo deals with the case of a drunk who died on a bus. There is little information about the man and the case becomes more of a puzzle when the autopsy reveals that he wasn't drunk at all.
- Harry is shocked when his former university girlfriend, Penny Harris, is brought in dead. She drove her car into a tree and the police initially suspect suicide but the autopsy reveals that the medication in her system was ground rather than in pill form, so they conclude she was likely murdered. Her husband tells the police that he thought his wife was having an affair and her parents react strangely to the news. Leo assists the police in the death of Jimmy Triangle, a conceptual artist whose latest work dealt with the death of conceptual art - and includes his own body, as he is shot through the head. The question is whether the shot was self-inflicted or not.
- Nikki and Harry continue to investigate the death of Penny Harris. Harry is shocked to learn that she had apparently at some point in her life had a child but her husband denies any knowledge of such. Another death in the Harris family allows them to narrow the suspects and identify the killer. Leo continues to look for clues and the police think they have solved the case through fingerprint evidence, but Leo is able to prove that the suspect has been framed. The victim's penchant for videotaping his activities provides a vital clue.
- Alison Garland is a 14 year old schoolgirl found dead on the school grounds just after lunch. She appears to have slit her wrists and committed suicide, but there is also evidence that she had sexual relations just earlier that day. As Leo Dalton looks into the case he learns that Alison was also a school bully and was a very unhappy young woman. Harry assists the police in the stabbing death of a car dealer. The evidence suggests that he was stabbed in his garage and his body then dumped. The case takes a radical twist when they find that the knife found by Alison's body was also used to kill the car dealer. Nikki assists the police in the death of an elderly woman who appears to have been maltreated.
- A third murder is discovered on school grounds and Leo realises the killings are connected to a sinister teenage pact. Meanwhile, Nikki proves her elderly victim died of hypothermia - but there is still a guilty party to be caught.
- Harry and Nikki deal with the case of a young woman who is found dead in an animal shelter. Her dead body has obviously been posed and the autopsy reveals she may have been tortured before death. Information from police intelligence suggests that they may be dealing with a group of radical animal rights activists. It all becomes quite personal for Harry when Nikki is taken prisoner. It's also a difficult time for Leo who has been asked to appear before a medical council hearing and testify on the propriety of a close friend's medical research. Harry has been offered a prestigious chair at an American university, but has had difficulty discussing the issue with his colleagues, especially Nikki.
- Harry and the police desperately search for Nikki as they continue to find more bodies. The animal rights activists' target is a well known pharmaceutical firm that is undertaking research on behalf of the government. Leo finally decides on a course of action in testifying at the medical council hearing.
- The pathologists investigate when a military helicopter crashes into a refugee detention center. Harry and Nikki actually witnessed the crash and were first on the scene but the case is complex since the center was Ministry of Defense property leased to the Home Office. The team is shocked at the conditions they find in the center and Harry, who has a close friend in the RAF, is shaken when a government Minister attributes the accident to pilot error.
- Harry Cunningham is asked to review a case in a insurance dispute. The insurance company is refusing to pay out on an policy when the autopsy results show that the woman was intoxicated and likely was responsible for the fall that killed her. Her family insists that that is impossible as she was an abstainer. Nikki Alexander investigates when human remains are found buried in an field. The locals believe the body to be that of Clara Young, who had disappeared 18 months before. The remains are found on the site of a travelers or gypsy caravan site and the police are convinced that George Wood, one of the camp residents is responsible, but Nikki's evidence proves otherwise.
- George Wood is released by the police but he is soon found dead in his caravan. Although made to look like a suicide, it is clearly a murder. The case gets even more complicated for Nikki and the authorities when she determines that there are the remains of two victims in the field, not just one. The evidence in the George Wood murder points to someone with connections to the police. Harry Cunningham believes that the dead woman in his insurance case was likely suffering from dementia and looks to prove the cause
- The Lyell Center team solve more than just the original case that took them to Northern Ireland. Professor Ryan makes peace with her past and takes control of her future.
- Refer to part 1, as this is the continuing story of that.
- Sam is determined to find out how Dr. Sachs is able to pinpoint time of death so precisely, even if it means several convictions are overturned. A mother changes her plea to guilty, but Leo is still not satisfied that they have the truth. A loving daughter draws a picture for her prisoner dad that brings a confession. Dr. Sachs is found to have violated professional ethics, but what will serve the cause of justice best?
- The investigation continues and one of the survivors remembers a vital piece of information. It becomes evident that the identification of body 21 may also lead to the cause of the crash. In the end, the solution rests on discovering a an unknown romantic affair and marital betrayal.
- With the murder of the club manager, the pathologists also determine that the club owner shot his own girlfriend, likely by accident. They also identify an unlikely suspect in the shooting of the club manager. Harry and Nikki confront Leo over his abusive and unprofessional behavior.
- When a second police probationer dies at the police college, Sam concludes that they may be dealing with a copycat murder rather than a serial killer. The investigating officer thinks that a fellow probationer may have been responsible for the original murder but the college's commandant, whose son is a student there and soon to be a police constable, would like the reputation of the college protected and the whole thing swept under the carpet. Harry learns that his late friend's wife was prescribing the drugs he was taking and is not quite sure what to do with the information. Leo's relationship with his wife and daughter is stretched thin when he spends most of his time at work and they are left on their own.
- The team is approached by a support group of survivors from a recent train crash. What caused the tragedy, and what is the identity of the unidentified Body 21? When the mysterious body is named, Harry and Leo get closer to finding out what caused the train crash - with tragic consequences for one of the heroes of the disaster.
- Sam and Leo, colleague Pathologists, are on opposing sides of a high-profile court case.
- Unsatisfied with the progress of the case, Leo Dalton takes matters into his own hands trying to get in contact with an identity theft ring. The information he gathers assists the police and they work together. The death of one of the gang members, and a vital clue, lead police to identify the their leader, but in the end, the solution brings little solace to Leo.
- The police continue their investigation into the deaths of several members of the Irons family but based on the forensic evidence, they now believe he may have been killed elsewhere and then transported to his home. When one of Irons' two surviving children is killed, they look to his circle of friends and family for a possible motive. Thanks to Harry's information, the police investigate further into the death of an elderly woman who supposedly fell down the stairs in her home. Supt. Tony Ashton clearly wants to renew his friendship with Sam but she isn't so sure. Leo's home life is in turmoil and it's been affecting his work.
- The Director of January House tries to take his own life on the clinic grounds and the pathologists suspect they may have a case of adulterated prescription medication. Harry's repeat autopsy reveals that the young woman was also under medicated, but she had no contact with the clinic. The police suspect the wife in the case of the building society employee and Leo sets out to disprove her time line.
- The police and Harry find that a group of doctors are in a syndicate that owns race horses. One is a kidney Specialist and another is a Plastic Surgeon with a gambling problem. A young woman is going to pay for a kidney transplant privately as the National Health Service wait list is long. She and her husband wish to have a baby after that. There is a helicopter accident and it all becomes a complicated story to figure out for the team of Pathologists who have a temporary visitor called Nicki who is borrowing the lab to obtain a narrative about an Iron Age family whose bones she has to examine.
- Sam Ryan steals a toothbrush to get the DNA of the father of the unborn child of a suspected suicide. Tangled relationships between an athlete and his family are amplified when his body is found hanging in her apartment. Police arrest the athlete's brother-in-law after an anonymous tip. Harry's attempts at determining time of death by the growth of maggots give a wrong answer.
- With the death of a student from a drug overdose, the university must face the wrath of the girl's father, a major benefactor. The autopsy reveals that not only had she taken drugs but also that she had sexual relations with three different men in the previous 48 hours. Although the police have a suspect in the murder of Marcus Saul, new information suggests that the identity of the killer may lie in a completely different direction.
- The mystery of the severed arm is partly solved when the police discover a body floating in the river with a missing arm. The pathologists continue their investigation with little help from the police and DCI Deacon in particular. When she reveals to Tom that two of the men in the accident were undercover policemen, he realizes that Sam was correct and that he is being manipulated. The police refuse to tell them what is going on and Sam's interference has serious consequences. Harry continues to try and find a balance between detachment and compassion as one of the survivors of the crash seeks his assistance.