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- Geneticist David Sandstrom is the chief scientist at the prestigious virology/micro-biology NORBAC laboratory, a joint enterprise between the USA, Canada and Mexico for countering bio-terrorism.
- After a homemaker discovers that her husband is a philanderer, she imprisons him in their soundproof basement and reports him missing to the police.
- Inspector Diane Caligra of the Toronto Police Department is in somewhat of a conundrum. Detective Aidan Black, who currently is assigned to the SWAT team, is one of her best and most seasoned members, but she realizes based on his recent professional history and behavior, that he may be suffering from some mental illness, most likely post traumatic stress syndrome. She reassigns him to the newly formed Psych Crimes & Crises unit, which will deal with cases which involve some sort of emotional disturbance at its core. The unit was created by forensic psychiatrist Dr. Daniella Ridley, who will become his partner despite she not being a trained police officer. The other two members of the unit are the eager but inexperienced Detective Poppy Wisnefski, and tough but caring psychiatric nurse Leo Beckett. The two teams are to patrol when not working on a specific case. That first case is of Toby Burke, an aspiring hockey player who was murdered in the bedroom that he shared with his younger brother, Wyatt Burke, who was also in the room at the time of the incident. Toby died of a stab wound to his mid-section, but had a light bulb sticking out of that wound. Beyond the differences in opinions and approaches between Aidan and Daniella, they have to figure out if Toby's seemingly distraught father, Garrett Burke, knows more than he is disclosing, and figure out if there is some significance to the light bulb. Through this case, Aidan realizes that Diane had ulterior motives for placing him on this assignment despite the less than obvious fit: she wants Daniella to watch over him and provide her with a medical diagnosis of his mental condition.
- President Kirkman and his team receive credible intelligence that a dirty bomb is on U.S. soil, Emily asks Chuck to help her with something that has dangerous and illegal consequences.