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- A dramatization of the relationship between heart surgery pioneers Alfred Blalock and Vivien Thomas.
- An African-American woman becomes an unwitting pioneer for medical breakthroughs when her cells are used to create the first immortal human cell line in the early 1950s.
- A man and his HIV-positive twin take an insurance company to court over a possibly life-saving bone marrow transplant.
- During World War II and the era of staunch racial segregation, a Black carpenter's son named Vivien Thomas, who had a talent for surgery, along with a white surgeon named Dr. Alfred Blalock, who defied the medical establishment created a partnership that changed the course of cardiac surgery. With only a high school diploma, Thomas became a leading cardiac pioneer and educator of two generations of the United States' premiere heart surgeons. This moving documentary tells the story of Thomas and his relationship with Blalock, one that ushered in advances in surgery that are still in existence today.