Frank Reicher plays Dr. Wells, who experiments with a gorilla. Eleven years earlier, Reicher had an encounter with another gorilla in King Kong (1933).
Last of four "Gildersleeve" films released by RKO from 1942 to 1944 based on the popular NBC Radio Network program that aired from 1941 to 1958.
Marjorie's leopard costume seen at the beginning of the film was previously worn by Dolores Del Río in Journey Into Fear (1943).