At the time this series was developed, Ralph Bakshi had an infant son who got mad whenever Daddy had to go to work. He would throw his bottle at Bakshi as he was heading for the door. This is what gave Bakshi the inspiration for "Diaper Man, the hero who fights villains with his mighty bottle".
This series was created by Ralph Bakshi at a pitch session where Terrytoons offered their TV series concepts to the CBS executives, only to have them all rejected. While the producers were in shock and preparing for unemployment, the network executives asked the group if there were any other concepts they could hear about. Bakshi, a junior animator who was allowed to sit in on the session provided he sat down and stayed quiet, immediately spoke up and improvised the concept for the Mighty Heroes series in front of the executives. The idea was accepted by them and Bakshi was given responsibility for directing it.
The series aired as a Saturday morning cartoon TV series that had a Mighty Heroes episode divided into two parts and a classic Mighty Mouse episode shown in between the two-part Mighty Heroes episode.