Many of the 500 Florida frogs and 100 South American cane toads purchased for use in the film escaped during production.
Due to the film's low budget, no live birds were used for the bird attack scene in it. Stock footage of flying birds was superimposed over footage of the running cast.
Ray Milland wore a toupee throughout filming. He sweated so much that it fell off of his head several times.
In a review for "Andy Warhol's Interview", writer Fran Lebowitz called this film "the best bad movie I have ever seen in my life."
The Florida Holiday Inn used by the crew would not allow the venomous snakes, spiders, or scorpions used in the film to be brought into the hotel.