Tom Everett Scott had never been to Europe, stating: "I hadn't left the country. So it was a really big, brand new experience for me, and I got to work with all these great special effects people and we got to climb all over the Eiffel Tower at night. They would shut it down from midnight to 6 a.m. for our production. I don't know how many people get the opportunity to do that but that was a real thrill. We got to run around Paris in the middle of the night, and as a 26-year-old guy who had never been to Europe, I was just fascinated and felt very fortunate."
The church at the end is called Saint de Loup; "loup" is French for "wolf".
In a scene that was deleted from the movie, it was discovered that the werewolf society had been around for centuries and the werewolf that attacked David Kessler and Jack Goodman in An American Werewolf in London was once a member.
Julie Bowen commented on the makeup: "I'd go to work at 3:30 in the morning for a 9 0'clock call. The makeup guys were very funny and very sympathetic, there are times when you're sitting in the chair, and you're fine, and then all of a sudden you have an attack of, 'Oh my god, I can't sit for another minute!' and you have to jump around [Wearing nearly-opaque contact lenses,] you're just praying that you're going to hit your mark and say your line at the right time. It is definitely a challenge."