Both the Romy and Michele characters were originated in the stage play "Ladies Room." Lisa Kudrow reprises the role she played in it.
In the dream reunion scene, when Romy and Michelle are on stage to receive their award, you can see just above the stage in the lights that are strung what looks like a banana on one side, and a carrot on the other just like the magnets that Christie put on Michelle's back brace in high school.
An Oscar-winner and rising star at the time, Mira Sorvino's career was all but ruined by Harvey Weinstein when he blacklisted her in Hollywood in retaliation for refusing his advances. Peter Jackson wanted to cast her in a major role in his Lord of the Rings trilogy, but Weinstein forbade it.
Alan Cumming owns a bar in New York City called Club Cumming where every Saturday the bar hosts a Romy and Michele themed day involving 90s music, DJ requests written on Post-It notes, and scarf folding stations.
Lisa Kudrow received a degree in Biology from Vassar College, and Mira Sorvino a degree in Asian Studies from Harvard University, so during production of Romy and Michele, they nicknamed each other "Smart" and "Smarter."