Alex goes undercover as a costumed "freak" named Red Talon and befriends Overlord's brutish shark-like lieutenant, Mako, in order to infiltrate Overlord's gang, the Vicious Circle, and thwart their plan to poison the city water supply.
Overlord's henchmen Open Face and Octopus steal experimental quantum magnetics technology to create Dragonsmasher, a large robot programmed to destroy Dragon. Dragon also deals with a shady congressional candidate.
When Dragon's overly enthusiastic fan and younger female equivalent, the She-Dragon, botches a police sting, the two Dragons must team up to save Alex from Mako's gang and stop Overlord from using a supermicrochip to take over the city.
Dragon finally manages to apprehend Overlord, but the crime lord orders Bludgeon to kidnap Barbaric's spunky kid sister (who is not a mutant), forcing the good mutant to help him take revenge on Dragon.
Ma's biker gang joins Overlord's Vicious Circle. As a publicity stunt, She-Dragon is accepted into the force and becomes Dragon's new partner to his great annoyance. However, she only cares about taking down Overlord, not serving the law.
OpenFace creates a giant, monstrous, nigh unstoppable Bride for Arachnid. Unfortunately, his assistant Octopus accidentally replaces her brain with the brain of an always hungry mutant and she goes on a rampage.
Overlord convinces the brooding Dragon that he himself was the original Overlord. Disillusioned, Dragon quits the force and goes on a rampage to end Overlord and his gang once and for all. Series finale.
Dragon puts She-Dragon in protective custody at Barbaric's place after she tries taking on a rampaging female mutant biker gang consisting of Volcanic, Vein and their leader with a maw for a stomach, Ma.
Alex is hurt while trying to stop Lowblow and his hulking partner, Bludgeon, who rob banks for Overlord. Alex's bigoted new boyfriend blames Dragon for this, especially after Bludgeon goes after immobile Alex to get back at Dragon.
Dragon arrives in Hospitality, a small southern town run by a bigoted sheriff, to find out what Overlord's henchmen, Basher and Doubleheader, are doing there. What he finds is Arachnid's insatiable hunger.