Even though Hugh Jackman, the actor who plays Wolverine in X2 (2003), is featured on the game's box art, he did not provide the voice for Wolverine, nor was his likeness used for the character's model. Instead, Wolverine was voiced by Mark Hamill, and is modeled after the character's appearance from the comics.
This is the second time Gwendoline Yeo has voiced Lady Deathstrike in an X-Men game. The fist being X-Men: Next Dimension (2002).