Both Leonardo DiCaprio and Ashton Kutcher were considered for the role of Dr. Niel Gardner's, but the producers later decided they were too young for the role. Finally, the choices were narrowed down to Ken Marino, Zach Braff, and Mark Feuerstein. The producers loved Ken Marino's sense of humor and chose him.
'Sofia Vergara' was one of the first to audition for the role of Sofia.
Martita Roca was first cast to play the leading role of Sofia, but then producers thought she would be better as Monica, Sofia's cousin.