The first short in the "World Premiere Toons"/ "What a Cartoon" series; which actually premiered the day before the official premiere of the series (The "World Premiere Toon-In," hosted by the characters from Space Ghost Coast to Coast (1993)) on 20 Febuary 1995.
Dexter's Laboratory: "Changes", was the first of the What A Cartoon! animated shorts to spin off into its own TV series. Cow and Chicken: "No Smoking" was the second What a Cartoon! short to spin off into a series.