Although released after Metroid Prime 2: Echoes (2004), the game chronologically takes place between Metroid Prime (2002) and Echoes.
A copy of the Metroid Prime: Hunters demo, entitled Metroid Prime Hunters: First Hunt, was included as a packaged bonus in the North American and European releases of the Nintendo DS handheld.
This is one of 2 Metroid Prime games where the soundtrack was not composed by Kenji Yamamoto, the other game being Metroid Prime: Federation Force which is another spin-off game.