- 7 of the 4400 have died and Maia gets worse all the time Out of suspicion and despair Diana threatens Dr. Hudson with a gun. Lily has run away with Isabelle and Richard pleads her to come back. Marsdem seems unable to avoid a long prison term which makes Alison contact Kyle.—Qultlifter
- As 4400 members begin to pass away from the illness, Diana and Tom discover that the very agency that they work for may be responsible for this illness in the first place. Meanwhile, Lily takes Isabelle on the run from everyone, including Richard. Alison reaches out to Kyle for help when it begins to look like Marsden will be convicted for the murder of Jordan Collier, putting Kyle in the position of either telling the truth or letting an innocent man get life in prison.
- On the heels of discovering that NTAC is behind the disease plaguing the 4400, Tom and Diana find themselves enveloped in a government conspiracy to hide the truth. Although the disease was an unforeseen side affect of an inhibitor secretly administered to the 4400 to prevent the emergence of special abilities, it's clear that the powers that be are more concerned with covering their tracks than curing the disease. Now Tom and Diana must face off against their own agency as they race against time to get to the bottom of NTAC's coverup and help find a cure before it's too late.
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