Bruce Timm has stated on various audio commentaries that he admires the Buffyverse, and in the "Rebirth, Part I" commentary he said that he was asked to make Batman Beyond like Buffy the Vampire Slayer, which was very popular of WB at that time. Curiously, one year and one month after the airing of this episode, Buffy aired an episode with plot points similar to this one, in which a misfit creates an android girlfriend, who also goes haywire in a party.
Stan Berkowitz stated he wanted to put Killer Croc in the show as his reptilian physiology allowed him a longer lifespan. However, other than this robotic version, he does not appear.
Max Brooks inadvertently believed that the producers were unhappy with his performance as Howard Groote. He just walked in and overheard complaints, which he thought were about him. (The complaints were actually about a then-released movie.) He was thus surprised when he was later asked to reprise Howard in later episodes, and the misunderstanding was resolved.
Max saying "Hope I wasn't out of line with that robo bim crack." is a likely reference to the series "Get Smart" in which Maxwell Smart, played by Don Adams, frequently says it after insulting someone and hitting them with no effect; Max Brooks's father, Mel Brooks, co-created Get Smart. And Max's voice actress, Cree Summer, had previously worked with Don Adams on Inspector Gadget. Previously, Lobo referred the Preserver's female robot guards as "robo bims" in the Superman: The Animated Series episode "The Main Man, Part II".
The GoLeM from its eponymous episode makes an appearance when Howard is exploring the synthoid factory.