- The team is called to a suburban house where the whole family, except the two daughters, have been murdered with no apparent motive.
- A teenage girl runs out of her house in the middle of the night screaming for help. The crime scene inside is a mess with four dead bodies, her father, mother and two brothers, lying in pools of blood. The only survivors are the oldest daughter,Tina, and Brenda, the youngest member of the family. Grissom assembles his team together and announces that this will be the only crime scene for his shift. Meanwhile, he assigns Sara to take care of Brenda, much to her dismay as she is not good with children. Nonetheless, during the course of the investigation, Sara discovers a maternal side in her.—Ploy P.
- When a teenager runs out of her house screaming for help, the police and the CSI team are summoned to investigate the case. They find that the father, mother and two siblings of the Collins family had been stabbed to death and only the teenager Tina Collins and her little sister Brenda have hidden and saved their lives. Along their investigation, the CSI scientists find mysteries and contradictions until they resolve the case.—Claudio Carvalho, Rio de Janeiro, Brazil
- A girl runs out of her house in pajamas screaming "Somebody help me! Please, God, help me!"
The mother, father, and two brothers of a family were murdered. The two sisters were spared.
Simon, an intern, follows Grissom through a preliminary walk-through of the house, taking his notes. The father, Stock Collins, is lying in a pool of blood where he died, a single-edged blade having stabbed him several times in the back and neck. Simon feels sick, and Sara takes over for him.
A blood swirl is left on the wall; Sara thinks it might be a cult symbol. The mother was stabbed once to the throat, likely while sleeping. A brother was found, killed in the same manner as his mother. The blood swirl is found, again, on the mirror. The younger brother was still alive when he died, his blood prints on the wall.
Grissom declares that "this is the only crime scene in Las Vegas tonight."
Grissom talks to Tina Collins, who is worried about her little sister, Brenda Collins (Dakota Fanning). Brenda offers only the cryptic "the buffalo."
The offending knife was taken from the house, and the killer had been in the house before. Grissom finds a footprint in the kitchen, but it belongs to the paramedics.
Grissom sends Sara to accompany Brenda Collins to the hospital, which Sara resents. She tries to talk with Brenda, who reacts badly. Tina is put through a psych evaluation. After an examination with psychiatrist Dr. Leever (Aasif Mandvi), a woman tries to take Brenda, but Sara refuses to leave her.
Catherine thinks the blood swirls are mimicry of cults. Grissom determines that the killings woke the father, who ran to protect Brenda. Catherine maps out the crime scene for hours on end, working past a time when she was supposed to pick up Lindsey. Instead, Eddie picked up their daughter, and had pancakes waiting for his ex when she got home. Unfortunately, at that moment, Grissom calls for her return. Later, Eddie files a complaint with social services against Catherine.
Warrick find treads from a scooter, one that a kid, Oliver, living nearby owns. It turns out that three other kids share the scooter. One had had sex with Tina, but was grounded. One had gone camping. The third, Jesse Overton, had also had sex with Tina and was with a church group. Jesse smokes the same kind of cigarettes with the same kind of matches that were found at the scene.
Grissom is busied with the fact that Tina Collins, who he'd presume would run to her family to see if they were still alive, didn't have a spot of blood on her clothing. Tina can't explain it.
Jesse throws away the scooter in his own trash can, along with his bloody clothes. Under a polygraph, Jesse confesses to all four murders, saying that Tina requested it of him. Jesse lies about the motive, so Grissom continues to investigate.
Catherine discovers that the father was actually killed, coming out of Brenda's room. The father had been sexually abusing Brenda, just like he had Tina. He wore a necklace with a buffalo on it. The mother and brothers were killed because they didn't protect either girls. As it turns out, Brenda is Tina's daughter with her father.
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