Stewie makes a comment along the lines of "Wouldn't it be funny if I turned out to be a homosexual?" Throughout the show's run, there are several jokes implying that Stewie is homosexual. Seth MacFarlane eventually confirmed the rumors and announced that Stewie is, in fact, gay.
First appearance of Buckey Baz.
On the Volume One DVD set, the description claims that there is a subplot in which Meg becomes a nanny to the Von Trapp children, but there is no such subplot in any version.
First appearance of Mayor Adam West.
After the Griffins get replaced on their reality show, Lois complains that her voice is not as nasally as Fran Drescher makes her sound. Ironically, Drescher and Lois are both voiced by Alex Borstein.