When talking to Carlton in one scene Will impersonates Muhammad Ali. Will Smith would eventually portray the legendary boxer in Ali (2001).
The episode title refers to Genesis 4:9, which reads "Then the LORD said to Cain, 'Where is your brother Abel?' 'I don't know,' he replied. 'Am I my brother's keeper?'"
This is Dave Florek's final Appearance, as Coach Smiley.
At the beginning of the episode when Will, Carlton, and their friends are celebrating, they sing "When The Saints Go Marching In" and chant "Who dat say..." Though the Bel Air Academy's mascot is the Saints, these are celebrations popularized by the fans of the NFL's New Orleans Saints.