Actress Linda Emond (Dr. Elizabeth Downy) has appeared in several different series in the L&O franchise playing a total of seven different characters (three of them doctors). She is most notably known for playing Dr. Emily Sopher on Law & Order: Special Victims Unit (1999), a neurobiologist who studies human behavior and is often called to testify as an expert witness on behalf of the defense. Emond has appeared in:
- Savior (1996) as Laura Cochran
- The Unthinkable (1997) as Nancy Carol
- Panic (2000) as Carolyn Tyler
- Anti-Thesis (2002) as Dr. Christine Fellowes
- Hate (2004) as Dr. Emily Sopher
- Mean (2004) as Dr. Emily Sopher
- Baby Boom (2005) as Dr. Emily Downey
- Tombstone (2005) as Rosalie Helton
- Unorthodox (2008) as Dr. Emily Sopher
- Hammered (2009) as Dr. Emily Sopher
- Spiraling Down (2011) as Dr. Emily Sopher
- Girl Dishonored (2013) as Dr. Emily Sopher
- Producer's Backend (2014) as Dr. Emily Sopher
Actor Aasif Mandvi has appeared in several different series in the L&O franchise, playing a total of eight different characters. He appeared in the following episodes:
- The Smoking Section (1995) as Omar
- Performance (1995) as Khan
- Slave (1996) as Technician
- Showtime (1997) as Gulab Singh
- Faccia a Faccia (1998) as Peanut Vendor
- Honor (2000) as Professor Husseini
- Inert Dwarf (2004) as Sateesh
- Baby Boom (2005) as Judge Samir Patel
- Bang & Blame (2005) as Judge Samir Patel
Actress Leslie Hendrix first (and only) appearance on this series as Dr. Elizabeth Rogers. Across the L&O franchise she played Chief Medical Examiner Elizabeth Rogers, M.D. in a total of 263 episodes. She also appeared in the made-for-TV movie Exiled (1998) which was about Detective Mike Logan, Chris Noth, while he was working at the Staten Island precinct.
Actress Isabel Glasser (Jean Nevins) has appeared as several different characters across the L&O franchise, including:
- Thin Ice (2000) as Patty Taylor
- Probability (2003) as Elaine Gergis
- Bound (2004) as Josette Brooks
- Baby Boom (2005) as Jean Nevins