Producer and Director Sheldon Leonard had appeared on "I Love Lucy" as Harry Martin, salesman for the Handy Dandy appliance company on "I Love Lucy" in "Sales Resistance" (S2;E17). He played himself on a 1967 episode of "The Lucy Show."
"Make Room for Daddy" shared at least one Desilu staff member with "I Love Lucy" and "The Lucy-Desi Comedy Hour," Production Manager (later Supervisor) W. Argyle Nelson.
Rusty Hamer (Rusty Williams) does not appear in this episode, despite being a regular cast member. He is, however, depicted in the show's opening credits. Coincidentally, Hamer also also did not appear in the 1971 cross-over between "Make Room For Granddaddy" and "Here's Lucy."
When "I Love Lucy" finished its half-hour format in 1957, "Make Room for Daddy" was given its prized Monday night time slot. To symbolize the show's "move" from ABC to CBS, a cross-over episode of "The Lucy-Desi Comedy Hour" titled "Lucy Makes Room for Danny" depicting the Williams Family moving (temporarily) into the Ricardo's Westport, Connecticut, home. "Lucy Upsets the Williams Household" was Desilu's way of repaying Danny Thomas productions for doing "Lucy Makes Room for Danny" a few months earlier.
Sandwiched between "Make Room for Daddy" and "The Westinghouse Desilu Playhouse" CBS aired yet another Desilu sitcom, "The Ann Sothern Show" (Desi Arnaz, Executive Producer), which also did a cross-over featuring Lucy Ricardo. Before Sothern's first series "Private Secretary" was canceled (due to a contract dispute), it, too, featured a cross-over with "The Lucy-Desi Comedy Show" with Susie McNamara (Ann Sothern) joining Lucy McGillicuddy for a singles cruise to Havana in 1940. On the evening of January 5, 1959, "The Ann Sothern Show" featured two of Lucille Ball's favorite character actors, Charles Lane and Sid Melton.