Rosanna Huffman here has her final guest role on the series. First guesting in the debut episode: The Murder of Sherlock Holmes (1984), Huffman had guested in one more episode: Keep the Home Fries Burning (1986), prior to the death of her husband: series creator Richard Levinson. Subsequently Huffman had guested in four further episodes, ''Dear Deadly'' being preceded by Trouble in Eden (1987), The Sins of Castle Cove (1989), and Jack and Bill (1989). With seven guest roles on ''Murder, She Wrote'', Huffman ranks as the series' most frequent guest actress.
Seth Jaffe plays a San Francisco Police Lieutenant with a cat allergy twice but with a slightly different names. In Dear Deadly (1994) he is Lieutenant Evans. In Death by Demographics (1996) he is Lieutenant Evers.
Although set in San Francisco, no scenes were actually filmed there.
Loretta Lee is played by the late Eileen Brennan and she is best known for playing Capt. Doreen Lewis in Private Benjamin (1981) She died on the 28th July 2013 (age 80)