Colonel Beckett (Michael Rooker) shakes hands with a doctor, killing him in the process with a deadly contact poison. Beckett, who comes from a plague stricken future, has been sent back in time to find and eliminate the person responsible for starting it all - Patient Zero. Although the scientists of the future know the DNA of three people combined to form the virus, they still do not know the identity of the one who came in contact with those three. During his search, Beckett is injured and nursed back to health by Amy, with whom he shares his secret. After discovering Amy had contact with the doctor, Beckett reveals her to be Patient Zero. He promises to remain in the past with Amy rather than killing her, but another operative appears, informing Beckett that HE is actually Patient Zero, since he came in contact with all three people while searching for Amy. Beckett sacrifices himself to save the future.