This is the first episode to be narrated by someone other than Meredith, in this case, George.
First appearance of Dr. Callie Torres (Sara Ramirez)
Every episode of the show is named after a famous song. "What Have I Done to Deserve This?" is a song by the Pet Shop Boys.
Both Noah Gray-Cabey and Patrick Dempsey are originally from Maine. Noah was raised in Newry, Maine and Patrick was born in Lewiston, and raised in nearby towns of Turner and Buckfield, Maine.