When Dean returns to the hotel room and finds Sam drunk he says "Come on, time for bed, let's go, Sasquatch." Sasquatch is Jensen Ackles' nickname for Jared Padalecki in real life.
When Sam and Dean are booking a room in the hotel, Susan tells them that their room number is 237. This is the same room number that plays a major plot point in The Shining (1980).
This episode is clearly modeled after the famous horror movie The Shining (1980). There are many parallels that reference The Shining, such as room 237, two little girls, the quote stating that "we can play together forever and ever and ever" , and the bar scene in which Dean talks with an older bartender.
Dean suggests a "greasy pork sandwich served up in a dirty ashtray" as a hangover remedy to Sam. This is a direct quote from the movie Weird Science (1985), the line was originally delivered by Chet Donnelly, played by Bill Paxton.
Jared Padalecki admitted that both he and Jensen Ackles were freaked out by the room full of porcelain dolls. As a prank, he made sure to put some in Ackles' trailer.