Michael Cera, who played Dean in episode 2.16, The Rapes of Graff (2006), was originally going to be the serial rapist until scheduling conflicts prevented him from returning to the show.
When Veronica (Kristen Bell) wakes up in the dorm and steps over Piz, who's sleeping on the floor, he asks her for an egg sandwich. She looks at him and Meryl (Amanda Walsh) and asks "Orange Whip?" This is a reference to John Candy's character in The Blues Brothers (1980) when he does the same thing at the concert.
Meryl's (Amanda Walsh) theory about Sully (Michael Grant Terry) accidentally inventing a "laser that can kill people from space" is a reference to the 1985 movie Real Genius (1985) starring Val Kilmer.
In this episode, Keith (Enrico Colantoni) breaks up with Harmony Chase (Laura San Giacomo) because Veronica (Kristen Bell) doesn't approve of the relationship. It's the second time he ends a relationship in order to please his daughter. The first time was in episode 1.5, You Think You Know Somebody (2004), when he broke up with Rebecca James (Paula Marshall), Neptune High School's guidance counselor.
When Veronica visits Mercer in jail, she says, "Well, you know what they say in the Big House: If you can't find a partner use a wooden chair. Let's rock." That's a line from Jailhouse Rock written by Jerry Leiber and Mike Stoller that first became a hit for Elvis Presley.