- An angel causes people to cheerfully go out to murder, and when the Winchesters investigate one of them falls under its sway.
- In Providence, Rhode Island, the local Gloria kills a man claiming that an angel in a beautiful white light had chosen her for redemption and asked her to stab the sinner to accomplish God's will. Dean and Sam investigate the case and they discover that other people had been visited by the angel and committed murders. Further, the angel has appeared after the death of Father Gregory, who was murdered on the steps of his church two months ago. When Sam is visited by the angel and asked to kill a man, the skeptical and atheist Dean confronts the faith of Sam telling that men cannot be angels and the light is an angry spirit indeed.—Claudio Carvalho, Rio de Janeiro, Brazil
- The Winchesters investigate a spate of murders committed by people who were apparently visited by an angel and told to carry out "God's will" and kill those who have sinned. For Sam it's easy to believe it to be the case. Not so easy for Dean, who believes they're dealing the confused and angry spirit of Father Gregory, a man murdered on the steps of his church in an attempted robbery. While checking up on a lead Sam is visited by the angel and told to kill someone.—Derfel85
- Sam, disguised as a nurse, interviews a woman in a psychiatric facility who murdered a man, Carl Gully, and claims an angel told her to do it. Sam returns to a motel room where Dean is keeping a low profile after his media exposure during the bank siege in Milwaukee. He relates her story and Dean scoffs at the idea of angels. They proceed to investigate Carl Gully's house, where they find a number of bodies buried.
Overnight another killing takes place - a man kills a stranger and says an angel told him who to kill. Investigating the victim's house, they find evidence on his computer that he was stalking a young girl over the Internet. Dean discovers that both victims attended the same church -- Our Lady of the Angels. The boys visit the church and speak to Father Reynolds, who has nothing helpful for them, until he mentions his fellow clergyman Father Thomas Gregory who was shot on the steps of the church. Dean thinks it may be Father Gregory, a vengeful spirit, making people kill parishioners whose guilty secrets he knew. Sam is skeptical; he thinks it may be God at work, and reveals to a startled Dean that he prays regularly.
The boys return to investigate the church's crypt where Father Gregory is buried. While in different rooms, an angel appears to Sam and tells him he will be given a sign of someone to kill, someone about to do evil. Dean still thinks it is the spirit of Father Gregory and suggests that they summon his spirit. As they buy the supplies necessary for the summoning, Sam sees the man he says the angel wants him to kill. Dean takes off after the man and tells Sam to go and perform a séance. Sam is interrupted by Father Reynolds just as the spirit of Father Gregory appears. Father Gregory thinks he is an angel, but Father Reynolds argues with him and finally puts his soul to rest by saying the Last Rites.
Meanwhile, Dean is following the man Sam had identified, and stops him as he is attacking a young woman. Dean chases him in his car until the man's car nearly collides with a truck. A metal pipe from the truck impales the man, killing him. Back at the motel, Sam explains to Dean why his faith is important to him. Dean describes how the man died, and says he thinks it may have been the hand of God at work.
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