Despite this being the final episode, Jeri Ryan did not appear. The Writer's Strike had shortened the number of episodes from 22 to 16 and her maternity leave was not yet over when it was being filmed.
On May 14th, 2008, before this episode aired, CBS announced that "Shark" would not return for a third season. Thus this acted as the series finale, and was advertised as so.
{Wayne's World 3: Killer Shark (#2.16)}