The lounge singer crooning a very bad version of "Kokomo" is significant since John Stamos (Tony Gates) appeared in The Beach Boys' 1988 video of the song playing both conga and steel drums.
The medical conference is in Omaha, Nebraska, which had a population around 406,000 and a metropolitan area population of 860 000 when this episode aired.
Archie Morris (Scott Grimes) mentions Lincoln is not too far from Omaha, which is true. Lincoln (population 288,000) is the state capital of Nebraska and the distance between borders of the two metro areas is only about 25 miles.
The title refers to the song "Let It Snow! Let It Snow! Let It Snow!" written by lyricist Sammy Cahn and composer Jule Styne in 1945.