Sheldon is correct in that a strawberry is not a fruit (it is derived from the ovary of a plant). It is actually an accessory fruit (derived from some tissue around the plant's ovary).
The hospital set where Leonard's hand is stitched is identical to the one from Two and a Half Men (2003), which was also created and written by Chuck Lorre. There are many TBBT and TAAHM cross over locales.
Sheldon (Jim Parsons) attempts to invoke "Starfleet General Order 104 Section A" to relieve Leonard (Johnny Galecki) of his command of his own relationship with Stephanie (Sara Rue). This section has not been clearly spelled out in a Star Trek episode, though the two sections that follow it (B and C) have.
This episode was watched by 10.19 million people with a rating of 3.9 (adults 18-49).