Tilda (Morgan Taylor Campbell), Juan (Iñaki Godoy), and Abbi (Rhianna Jagpal) are the titular imperfect test subjects of a genetic experiment. They start experiencing strange symptoms and turn to geneticist Dr. Alex Sarkov for help.
Juan spends time with his brother and niece. Tilda and Abbi meet with another experimental subject. Investigators with badges start looking for the Imperfects.
Abbi stays at the lab while Juan and Tilda follow a lead on Dr. Sarkov. Abbi meets with Hannah and discovers that Dr. Burke may be in danger from Isabel Finch.
After receiving bad news from home, Abbi attempts to replicate the cure. Juan attends a party. Tilda tries to warn Sarkov of the risks of using nanobots.
Abbi and Tilda band together with an unexpected ally to go after Sarkov, who has big plans for Juan. New revelations bring new challenges for the group.