During Lexi (Maude Apatow)'s "This is Life" sequence, Lexi names her imagined character Grace. In "Assassination Nation (2018), written & directed by the creator Sam Levinson, Apatow plays a character named Grace.
The episode won 2 Emmy Awards for Outstanding Choreography for Scripted Programming - Call Me Irresponsible and Outstanding Guest Actor in a Drama Series - Colman Domingo for playing Ali.
The "Euphoria" title card appears after more than 14 minutes, about a quarter of the way into the episode.
Eric Dane (who plays Cal) was also on Grey's Anatomy (2005), where his character also had a best friend named Derek.
Yann Demange, Victoria Mahoney, Cheryl Dunye, Charlotte Sieling, Misha Green, Jeffrey Nachmanoff, Nelson McCormick, and Minkie Spiro were offered to direct, but however, they turned down due to creator's differences with Cal's backstory, Rue's dance sequence, Cassie's meltdown, and Rue's drug dealing with Laurie.